Hot-Melt Extrusion / Advances in Pharmaceutical Technology (ePub)
Pharmaceutical Applications
(Sprache: Englisch)
Hot-melt extrusion (HME) - melting a substance and forcing it
through an orifice under controlled conditions to form a new
material - is an emerging processing technology in the
pharmaceutical industry for the preparation of various dosage forms
and...
through an orifice under controlled conditions to form a new
material - is an emerging processing technology in the
pharmaceutical industry for the preparation of various dosage forms
and...
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Hot-melt extrusion (HME) - melting a substance and forcing it
through an orifice under controlled conditions to form a new
material - is an emerging processing technology in the
pharmaceutical industry for the preparation of various dosage forms
and drug delivery systems, for example granules and sustained
release tablets.
Hot-Melt Extrusion: Pharmaceutical Applications covers
the main instrumentation, operation principles and theoretical
background of HME. It then focuses on HME drug delivery systems,
dosage forms and clinical studies (including pharmacokinetics and
bioavailability) of HME products. Finally, the book includes some
recent and novel HME applications, scale -up considerations and
regulatory issues. Topics covered include:
* principles and die design of single screw extrusion
* twin screw extrusion techniques and practices in the laboratory
and on production scale
* HME developments for the pharmaceutical industry
* solubility parameters for prediction of drug/polymer
miscibility in HME formulations
* the influence of plasticizers in HME
* applications of polymethacrylate polymers in HME
* HME of ethylcellulose, hypromellose, and polyethylene
oxide
* bioadhesion properties of polymeric films produced by HME
* taste masking using HME
* clinical studies, bioavailability and pharmacokinetics of HME
products
* injection moulding and HME processing for pharmaceutical
materials
* laminar dispersive & distributive mixing with dissolution
and applications to HME
* technological considerations related to scale-up of HME
processes
* devices and implant systems by HME
* an FDA perspective on HME product and process
understanding
* improved process understanding and control of an HME process
with near-infrared spectroscopy
Hot-Melt Extrusion: Pharmaceutical Applications is an
essential multidisciplinary guide to the emerging pharmaceutical
uses of this processing technology for researchers in academia and
industry working in drug formulation and delivery, pharmaceutical
engineering and processing, and polymers and materials science.
This is the first book from our brand new series Advances
in Pharmaceutical Technology. href="http://www.wiley.com/legacy/wileyblackwell/images/Advances_in_Pharmaceutical_Technology.pdf">Find
out more about the series here.
through an orifice under controlled conditions to form a new
material - is an emerging processing technology in the
pharmaceutical industry for the preparation of various dosage forms
and drug delivery systems, for example granules and sustained
release tablets.
Hot-Melt Extrusion: Pharmaceutical Applications covers
the main instrumentation, operation principles and theoretical
background of HME. It then focuses on HME drug delivery systems,
dosage forms and clinical studies (including pharmacokinetics and
bioavailability) of HME products. Finally, the book includes some
recent and novel HME applications, scale -up considerations and
regulatory issues. Topics covered include:
* principles and die design of single screw extrusion
* twin screw extrusion techniques and practices in the laboratory
and on production scale
* HME developments for the pharmaceutical industry
* solubility parameters for prediction of drug/polymer
miscibility in HME formulations
* the influence of plasticizers in HME
* applications of polymethacrylate polymers in HME
* HME of ethylcellulose, hypromellose, and polyethylene
oxide
* bioadhesion properties of polymeric films produced by HME
* taste masking using HME
* clinical studies, bioavailability and pharmacokinetics of HME
products
* injection moulding and HME processing for pharmaceutical
materials
* laminar dispersive & distributive mixing with dissolution
and applications to HME
* technological considerations related to scale-up of HME
processes
* devices and implant systems by HME
* an FDA perspective on HME product and process
understanding
* improved process understanding and control of an HME process
with near-infrared spectroscopy
Hot-Melt Extrusion: Pharmaceutical Applications is an
essential multidisciplinary guide to the emerging pharmaceutical
uses of this processing technology for researchers in academia and
industry working in drug formulation and delivery, pharmaceutical
engineering and processing, and polymers and materials science.
This is the first book from our brand new series Advances
in Pharmaceutical Technology. href="http://www.wiley.com/legacy/wileyblackwell/images/Advances_in_Pharmaceutical_Technology.pdf">Find
out more about the series here.
Autoren-Porträt von Dennis Douroumis
Dennis Douroumis University of Greenwich, UK
Bibliographische Angaben
- Autor: Dennis Douroumis
- 2012, 1. Auflage, 400 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 1118307879
- ISBN-13: 9781118307878
- Erscheinungsdatum: 24.04.2012
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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- Größe: 8.68 MB
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Sprache:
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