Hyaluronic Acid (PDF)

Hyaluronic acid is an essential part of connective, epithelial
and neural tissues, and contributes to cell proliferation and
migration. It is used as a stimulating agent for collagen synthesis
and is a common ingredient in skin-care products, a multi-billion
dollar industry, as it is believed to be a key factor in fighting
the aging process.

Hyaluronic Acid: Production, Properties, Application in
Biology and Medicine consists of six chapters discussing the
various issues of hyaluronic acid research. In Chapter 1, a
historical analysis recounts the discovery and milestones of the
research leading to the practical applications of hyaluronan.
Chapter 2 is dedicated to biological role of the hyaluronic acid in
nature, in particular in the human body. The chapter starts from
the phylogenesis of hyaluronic acid, then describes hyaluronan
functions in human ontogenesis and especially the role which
hyaluronan plays in extracellular matrix of the different tissues.
Chapter 3 describes the methods to manufacture and purify
hyaluronic acid, including the analytical means for assessing
quality of the finished product. Chapter 4 discusses the structure
and rheological properties of hyaluronic acid considering effects
on conformation and biological properties related to molecular
weight. In Chapter 5, the physical and chemical methods for
modifying the structure of hyaluronan are discussed including
cross-linking using bi-functional reagents, solid-phase
modification and effects of the combined action of high pressures
and shift deformation. The final chapter focuses on the products
derived from hyaluronic acid, including therapeutics composed of
modified hyaluronan conjugated to vitamins, amino acids and
oligo-peptides. The biological roles and medical applications of
this polysaccharide have been extensively studied and this book
provides a wealth of scientific data demonstrating the critical
role of hyaluronic acid and its promise as a multifaceted
bio-macromolecule.

Approaching hyaluronic acid from multiple angles, this book
links relationships between its biological functions, structure and
physical-chemical properties. It will be an invaluable
resource to researchers, both industrial and academic, involved in
all aspects of hyaluronan-based technologies.