Label-Free Technologies For Drug Discovery (PDF)

Over the past two decades the benefits of label-free biosensor
analysis have begun to make an impact in the market, and systems
are beginning to be used as mainstream research tools in many drug
discovery laboratories.

Label-Free Technologies For Drug Discovery summarises the
latest and emerging developments in label-free detection systems,
their underlying technology principles and end-user case studies
that reveal the power and limitations of label-free in all areas of
drug discovery.

Label-free technologies discussed include SPR, NMR,
high-throughput mass spectrometry, resonant waveguide plate-based
screening, transmitted-light imaging, isothermal titration
calorimetry, optical and impedance cell-based assays and other
biophysical methods. The technologies are discussed in relation to
their use as screening technologies, high-content technologies, hit
finding and hit validation strategies, mode of action and ADME/T,
access to difficult target classes, cell-based receptor/ligand
interactions particularly orphan receptors, and antibody and small
molecule affinity and kinetic analysis.

Label-Free Technologies For Drug Discovery is an
essential guide to this emerging class of tools for researchers in
drug discovery and development, particularly high-throughput
screening and compound profiling teams, medicinal chemists,
structural biologists, assay developers, ADME/T specialists, and
others interested in biomolecular interaction analysis.