Lysophospholipid Receptors (PDF)

The current state of the science supporting new research in
lysophospholipids

The study of lysophospholipids exploded with the discovery of
cell surface receptors on both lysophosphatidic acid (LPA) and
sphingosine 1-phosphate (S1P). Since then, thousands of original
research reports--ranging from fundamental cell signaling to
the physiology and pathophysiology of individual organ
systems--have centered on lysophospholipids. This book draws
together and analyzes the current literature to provide readers
with a state-of-the-science review as well as current techniques
that support research in all aspects of the field of
lysophospholipid signaling.

Lysophospholipid Receptors is divided into three
sections:

* Receptors and other possible effectors

* Enzymes

* Physiology and pathophysiology

Within each section, the authors explain the similarities and
differences between LPA and S1P signaling. Examples are provided
that demonstrate the underlying mechanisms of lysophospholipid
signaling across a broad range of organ systems, such as S1P
signaling in cardiovascular physiology and disease and the neural
effects of LPA signaling. Extensive references at the end of each
chapter provide a gateway to the literature and facilitate further
research into individual topics.

Each chapter has been authored by one or more leading
international authorities in lysophospholipid research. Based on a
thorough analysis of the current research, the authors set forth
what is established science and offer their expert opinion and
perspective on new and emerging areas of research, setting the
stage for further investigations that will solve current problems
in the field.