Metal Complex - DNA Interactions (PDF)

Metal ions and metal complexes have long been recognized as
critically important components of nucleic acid chemistry, both in
regulation of gene expression and as promising therapeutic agents.
Understanding how metal complexes interact with DNA has become an
active research area at the interface between chemistry, molecular
biology and medicine.

Metal Complex - DNA Interactions provides a comprehensive
overview of this increasingly diverse field, presenting recent
developments and the latest research with particular emphasis on
metal-based drugs and metal ion toxicity. The text is divided into
four parts:

* Basic Structural and Kinetic Aspects: includes chapters
on sequence-selective metal binding to DNA and thermodynamic
models.

* Medical Applications: focuses on anticancer platinum
drugs, including discussions on DNA repair in antitumor effects of
platinum drugs and photo-dynamic therapy.

* DNA-Recognition - Nucleases and Sensor: describes
probes for DNA recognition, artificial restriction agents,
metallo-DNAzymes for metal sensing applications and metal ion
dependent catalysis in nucleic acid enzymes.

* Toxicological Aspects: deals with structural studies of
mercury-DNA interactions, chromium-induced DNA damage and
repair, and the effect of arsenic and nickel on DNA
integrity.

This book will be a valuable resource for academic researchers
and professionals from a range of pharmaceutical and chemical
industries, particularly those involved in the development of new
and less toxic anticancer metallo-drugs, and in the field of
environmental and toxicological chemistry.