Prodrugs and Targeted Delivery / Methods and Principles in Medicinal Chemistry Bd.47 (PDF)
Towards Better ADME Properties
(Sprache: Englisch)
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the...
sofort als Download lieferbar
eBook (pdf)
165.99 €
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
Produktdetails
Produktinformationen zu „Prodrugs and Targeted Delivery / Methods and Principles in Medicinal Chemistry Bd.47 (PDF)“
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Inhaltsverzeichnis zu „Prodrugs and Targeted Delivery / Methods and Principles in Medicinal Chemistry Bd.47 (PDF)“
I PRODRUG DESIGN AND INTELLECTUAL PROPERTY Prodrug strategies in drug design The molecular design of prodrugs by functional group Increasing lipophilicity for oral drug delivery II PRODRUGS ADDRESSING ADMET ISSUES Modulating solubility through prodrugs for oral and IV drug delivery Topical and transdermal delivery using prodrugs: mechanism of enhancement Ocular delivery using prodrugs Prodrugs designed to target transporters for oral drug delivery Enzyme-activated prodrug strategies for site-selective drug delivery Reducing Pre-systemic Drug Metabolism III CODRUGS AND SOFT DRUGS Prodrug approaches for central nervous system delivery Soft drugs Improving the use of drug combinations through the codrug approach The impact of pharmacogenetics on the clinical outcomes of prodrugs IV PRECLINICAL AND CLINICAL CONSIDERATION FOR PRODRUGS Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites Pharmacokinetic and biopharmaceutical considerations in prodrug discovery and development Directed enzyme prodrug therapies
Autoren-Porträt
Jarkko Rautio is professor of pharmaceutical chemistry and head of the multidisciplinary Pharmaceutical and Medicinal Chemistry (PMC) research group at the School of Pharmacy, University of Eastern Finland (formerly University of Kuopio), where he received his PhD in pharmaceutical chemistry in 2000. He subsequently carried out his postdoctoral studies at the University of Maryland, Baltimore, USA, and was a visiting scientist at GlaxoSmithKline, North Carolina, while also co-founding the American Association of Pharmaceutical Scientists (AAPS) Prodrug Focus Group in 2005. Professor Rautio's research focuses on chemistry-based methods, especially prodrugs, to overcome the liabilities of drugs.
Bibliographische Angaben
- 2010, 1. Auflage, 496 Seiten, Englisch
- Herausgegeben: Jarkko Rautio
- Verlag: Wiley-VCH
- ISBN-10: 3527633170
- ISBN-13: 9783527633173
- Erscheinungsdatum: 29.11.2010
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: PDF
- Größe: 8.26 MB
- Mit Kopierschutz
Sprache:
Englisch
Kopierschutz
Dieses eBook können Sie uneingeschränkt auf allen Geräten der tolino Familie lesen. Zum Lesen auf sonstigen eReadern und am PC benötigen Sie eine Adobe ID.
Kommentar zu "Prodrugs and Targeted Delivery / Methods and Principles in Medicinal Chemistry Bd.47"
Schreiben Sie einen Kommentar zu "Prodrugs and Targeted Delivery / Methods and Principles in Medicinal Chemistry Bd.47".
Kommentar verfassen