Modulation of Host Gene Expression and Innate Immunity by Viruses (PDF)

In this book a number of groups leading this area of research have presented reviews and updates of their research. In the introductory chapter M Shaw and P Palese review the IFN signaling pathways and provide a comprehensive list of virus-encoded proteins that target different components of the pathways of the IFN response. It is then reviewed how viruses elicit the IFN production (DE Levy and IJ Marié), how IFN regulatory genes are induced by viruses (group of GC Sen), how viruses have ‘learned’ to evade immune mechanisms, interfering with MHC mediated antigen presentation, blockage of apoptosis, mimicking of cytokines and cellular receptors, or by direct infection of immune cells (group of HL Ploegh). In additional chapters, the virus-encoded IFN antagonists of particular viruses are described, such as of influenzaviruses (A Garcia-Sastre), paramyxoviruses (group of RE Randall), herpes simplex virus (SJ Advani and B Roizman), poxviruses (JB Johnston and G McFadden), filoviruses, bunyaviruses and flaviviruses (CF Basler). For poxviruses, the mechanisms of molecular mimikry, i.e. viral proteins binding to cytokines or cytokine receptors, are of particular interest. A new area of research is the involvement of toll-like receptors in the activation of pathways of the innate immune response and of their interaction with viral proteins (SR Ross). Autophagy is a protective mechanism of mammalian cells that can be targeted by viral virulence gene products (group of B Levine). Finally, the ways in which the genetic variation of hosts influences the susceptibility to viral infections is reviewed in a short chapter with particular attention to infection with HIV (E Choi and S Chanock).

There is minimal overlap between the different chapters, and the references are very up-to-date (a considerable number of them published in 2004). In several chapters the years of publication of references are omitted for no obvious reasons. Some chapters would have benefited from the presence of illustrations and tables.

This book is an excellent, up-to-date reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Thus, the book will be of great interest to virologists, molecular immunologists and biologists, and biochemists but also to clinical pharmacologists in the long-term search for new antiviral agents.

Gif-sur-Yvette/Cambridge,

Ulrich Desselberger