Molecular, Cellular, and Metabolic Fundamentals of Human Aging (ePub)

Name: Molecular, Cellular, and Metabolic Fundamentals of Human Aging
Brand: Elsevier Science & Techn.
SKU: 145565482
Price: 134.70 EUR
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(Sprache: Englisch)

Autoren: Evandro Fei Fang , Linda Hildegard Bergersen , Brian C. Gilmour

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Molecular, Cellular, and Metabolic Fundamentals of Human Aging, Evandro Fei Fang, Linda Hildegard Bergersen, Brian C. Gilmour

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Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how...

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Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion.

The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.

Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer's disease
Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging
Highlights recurring themes and key principles shared across the hallmarks of aging
Considers NAD+ depletion and defective autophagy as emerging aspects that impact human aging

Autoren-Porträt von Evandro Fei Fang, Linda Hildegard Bergersen, Brian C. Gilmour

Evandro Fei Fang is a molecular gerontologist and is currently Associate Professor at the Department of Clinical Molecular Biology, University of Oslo and the Akershus University Hospital, Norway. He has an extensive track record of mechanistic studies on human aging and mitophagy, and his main research interests currently center on exploring the basic molecular mechanisms of human ageing and age-related diseases, with a final goal to develop interventional strategies to improve people's lifespan and healthspan. He is currently pursuing the development of novel anti-ageing compounds using artificial intelligence combined with a cross-species wet-lab validation. Dr. Fang is also co-founder of the Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian anti-Alzheimer's disease (NO-AD) networks.

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Bibliographische Angaben

Autoren: Evandro Fei Fang , Linda Hildegard Bergersen , Brian C. Gilmour
2022, 260 Seiten, Englisch
Verlag: Elsevier Science & Techn.
ISBN-10: 032391618X
ISBN-13: 9780323916189
Erscheinungsdatum: 23.10.2022

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Dateiformat: ePub
Größe: 15 MB
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