Nuclear Organization in Development and Disease (PDF)
Novartis Foundation Symposium, No. 264
(Sprache: Englisch)
This book draws together contributions from cell and developmental
biologists, structural biologists, geneticists and clinical
scientists aimed at a better understanding of the cellular and
molecular basis of these diseases. Topics include:
* How...
biologists, structural biologists, geneticists and clinical
scientists aimed at a better understanding of the cellular and
molecular basis of these diseases. Topics include:
* How...
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Produktinformationen zu „Nuclear Organization in Development and Disease (PDF)“
This book draws together contributions from cell and developmental
biologists, structural biologists, geneticists and clinical
scientists aimed at a better understanding of the cellular and
molecular basis of these diseases. Topics include:
* How nuclear structure and location within a nucleus affect gene
expression
* Chromatin organization and cell differentiation
* The nature of the interactions between the nuclear envelope and
the cytoskeleton
* The extent to which the cytoskeleton mediates communication
between the cell membrane and nucleus in regulating gene expression
and whether disruption of such communication might underlie the
disease processes
It is hoped that a better understanding of the mechanisms
leading to disease pathogenesis may ultimately lead to more
rational and appropriate treatments.
biologists, structural biologists, geneticists and clinical
scientists aimed at a better understanding of the cellular and
molecular basis of these diseases. Topics include:
* How nuclear structure and location within a nucleus affect gene
expression
* Chromatin organization and cell differentiation
* The nature of the interactions between the nuclear envelope and
the cytoskeleton
* The extent to which the cytoskeleton mediates communication
between the cell membrane and nucleus in regulating gene expression
and whether disruption of such communication might underlie the
disease processes
It is hoped that a better understanding of the mechanisms
leading to disease pathogenesis may ultimately lead to more
rational and appropriate treatments.
Inhaltsverzeichnis zu „Nuclear Organization in Development and Disease (PDF)“
Chair's Introduction (R. Goldman). Nuclear lamins: building blocks of nuclear structure and function (R. Goldman, et al.). Aspects of nuclear envelope dynamics in mitotic cells (B. Burke, et al.). Components of the nuclear envelope and their role in human disease (H. Worman). Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease (K. Wilson, et al.). Identification of novel integral membrane proteins of the nuclear envelope with potential disease links using subtractive proteomics (E. Schirmer, et al.). Genetics of laminopathies (R. Ben Yaou, et al.). Muscular dystrophies related to the cytoskeleton/nuclear envelope (K. Nowak, et al.). Skeletal and cardiac muscle defects in a murine model of Emery-Dreifuss muscular dystrophy (M. Grattan, et al.). Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for Sir-mediated repression (A. Taddei, et al.). A-type lamin-linked lipodystrophies (C. Vigouroux and J. Capeau). Cytoskeletal defects in amyotrophic lateral sclerosis (motor neuron disease) (J. Julien, et al.). LMNA mutations in progeroid syndromes (S. Huang, et al.). A genetic approach to study the role of nuclear envelope components in nuclear positioning (D. Starr and M. Han). General Discussion I. A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development (A. Margalit, et al.). Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy (S. Kozlov, et al.). The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C-deficient cells (J. Lammerding and R. Lee). Chair's summing up (R. Goldman). Index of contributors. Subject index.
Autoren-Porträt
The Novartis Foundation is an international scientific andeducational charity which promotes the study and general knowledge
of science and in particular encourages international co-operation
in scientific research.
Chair: Robert D. Goldman
Bibliographische Angaben
- 2005, 1. Auflage, 300 Seiten, Englisch
- Herausgegeben: Derek J. Chadwick, Jamie A. Goode
- Verlag: John Wiley & Sons
- ISBN-10: 0470093749
- ISBN-13: 9780470093740
- Erscheinungsdatum: 05.08.2005
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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