Pharmacokinetics and Metabolism in Drug Design / Methods and Principles in Medicinal Chemistry Bd.29 (PDF)
(Sprache: Englisch)
In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development...
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In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs.
While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.
While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.
Inhaltsverzeichnis zu „Pharmacokinetics and Metabolism in Drug Design / Methods and Principles in Medicinal Chemistry Bd.29 (PDF)“
PHYSICOCHEMISTRY Partition and Distribution Coefficient as Measures of Lipophilicity Limitations on the Use of Octanol Further Understanding of log P Alternative Lipophilicity Scales Computational Approaches to Lipophilicity Membrane Systems to Study Drug Behaviour NEW: Dissolution and Solubility NEW: Ionisation (pKa) PHARMACOKINETICS Intravenous Administration: Volume of Distribution Intravenous Administration: Clearance Clearance and Half-Life Intravenous administration: Infusion Oral Administration Repeated Doses Development of the Unbound (Free) Drug Model Unbound Drug and Drug Action Unbound Drug Model and Barriers to Equilibrium Slow Offset Compounds Factors Governing Unbound Drug Concentration ABSORPTION The Absorption Process Dissolution Membrane Transfer Barriers to Membrane Transfer Models for Absorption Estimation Estimation of Absorption Potential Computational Approaches DISTRIBUTION Membrane Transfer Access to the Target Brain penetration Volume of Distribution and Duration Distribution and Tmax CLEARANCE The Clearance Processes Role of Transport Proteins in Drug Clearance Interplay Between Metabolic and Renal Clearance Role of Lipophilicity in Drug Clearance RENAL CLEARANCE Kidney Anatomy and Function Lipophilicity and Reabsorption by the Kidney Effect of Charge on Renal Clearance Plasma Protein Binding and Renal Clearance Balancing Renal Clearance and Absorption Renal Clearance and Drug Design METABOLIC (HEPATIC) CLEARANCE Function of Metabolism (Biotransformation) Cytochrome P450 Other oxidative processes Oxidative Metablism and Drug Design Non-Specific Esterases Prodrugs to Aid Membrane Transfer Enzymes Catalysing Drug Conjugation Stability to Conjugation Processes Pharmacodynamics and Conjugation TOXICITY Toxicity Findings Importance of dose size Toxicity of selected compound classes Stratification of Toxicity Toxicity Prediction - Computational Toxicology Toxicogenomics Enzyme Induction (CYP3A4) and Drug Design Enzyme Inhibition and Drug Design
... mehr
INTERSPECIES SCALING Objectives of Allometric Scaling Allometric Scaling Species Scaling: Adjusting for Maximum Life-Span Potential Species Scaling: Incorporating Differences in Metabolic Clearance Inter-Species Scaling for Clearance by Hepatic Uptake Elimination Half-Life NEW: Scaling to pharmacological effect NEW: Single animal scaling HIGH(ER) THROUGHPUT ADME STUDIES The HTS Trend Drug Metabolism and Discovery Screening Sequences Physicochemistry Absorption / Permeability Pharmacokinetics NEW: Metabolism and Inhibition NEW: The concept of ADME space Computational Approaches in PK and Metabolism Prediction Outlook
... weniger
Autoren-Porträt von Dennis A. Smith, Han van de Waterbeemd, Don K. Walker
The authors are leading scientists in the Drug Metabolism department of Pfizer, one of the top five pharmaceutical companies in the world.
Bibliographische Angaben
- Autoren: Dennis A. Smith , Han van de Waterbeemd , Don K. Walker
- 2006, 2. Auflage, 187 Seiten, Englisch
- Verlag: Wiley-VCH
- ISBN-10: 3527608281
- ISBN-13: 9783527608287
- Erscheinungsdatum: 21.08.2006
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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