Photosensitisers in Biomedicine (PDF)
(Sprache: Englisch)
Photosensitisers in Biomedicine offers clear and
comprehensive coverage of the many different photosensitiser types,
including information on their many applications that now extend
beyond anticancer therapy. These applications now...
comprehensive coverage of the many different photosensitiser types,
including information on their many applications that now extend
beyond anticancer therapy. These applications now...
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Photosensitisers in Biomedicine offers clear and
comprehensive coverage of the many different photosensitiser types,
including information on their many applications that now extend
beyond anticancer therapy. These applications now include
photoantimicrobial treatments not only in microbial disease, but
also in the microbial resistance to conventional drugs, which is
circumvented by photomicrobial action. The application of
photoantimicrobials in biological fluids is also of considerable
importance in the current era of HIV and is discussed in the book.
This text offers the most up-to-date coverage of
photodynamic therapy including information on how photosensitisers
have evolved within the field of cancer therapy and more recently
antimicrobial research. There are few books on the market that take
the approach of this text, as many are either conference based or
focus on the chemistry of photosensitisers.
Photosensitisers in Biomedicine is clearly defined into
three distinct parts beginning with a clear introduction to the
various types of photosensitisers. The book then moves on to
discuss the chemistry of photosensitisers and closes with their
numerous applications, for example, photodynamic therapy,
photodiagnosis, photodynamic antimicrobial chemotherapy (PACT) and
other non-oncological applications such as optical, arterial
plaques and stents.
comprehensive coverage of the many different photosensitiser types,
including information on their many applications that now extend
beyond anticancer therapy. These applications now include
photoantimicrobial treatments not only in microbial disease, but
also in the microbial resistance to conventional drugs, which is
circumvented by photomicrobial action. The application of
photoantimicrobials in biological fluids is also of considerable
importance in the current era of HIV and is discussed in the book.
This text offers the most up-to-date coverage of
photodynamic therapy including information on how photosensitisers
have evolved within the field of cancer therapy and more recently
antimicrobial research. There are few books on the market that take
the approach of this text, as many are either conference based or
focus on the chemistry of photosensitisers.
Photosensitisers in Biomedicine is clearly defined into
three distinct parts beginning with a clear introduction to the
various types of photosensitisers. The book then moves on to
discuss the chemistry of photosensitisers and closes with their
numerous applications, for example, photodynamic therapy,
photodiagnosis, photodynamic antimicrobial chemotherapy (PACT) and
other non-oncological applications such as optical, arterial
plaques and stents.
Inhaltsverzeichnis zu „Photosensitisers in Biomedicine (PDF)“
Author's introduction. PART 1: INTRODUCTION. 1. Light. 1.1 Electromagnetic radiation in everyday life. 1.2 Radiation and tissue. 1.3 Light, electrons and molecules. 1.4 Photoreaction. 1.5 Dental/plastics curing. 1.6 Photoaging/photofading/photobleaching. References. 2. Dyes and stains. 2.1 Dye use. 2.2 Textile dyeing and biological staining. 2.3 Biological stains and biomedical photosensitisers. 2.4 The human factor. 2.5 Dyes and drug development. 2.6 Dyes and stains and photosensitiser design. References. 3. Photosensitisers and photosensitisation. 3.1 Photosensitiser action. 3.2 The photodynamic effect and cell death. 3.3 Photosensitising drug discovery. 3.4 Fitness for purpose. 3.5 Organic versus inorganic photosensitisers. References. PART 2: CHEMISTRY OF PHOTOSENSITISERS. 4. Azines. 4.1 Acridines. 4.2 Acridine synthesis. 4.3 Rationale. 4.4 Acridines in photodynamic therapy. 4.5 Phenanthridines. 4.6 Phenaziniums. 4.7 Phenoxaziniums. 4.8 Phenothiazinium derivatives. 4.9 Reduction--oxidation activity. 4.10 Hydrophilicity?lipophilicity. 4.11 Molecular planarity. 4.12 Benzannelated derivatives. 4.13 Synthetic approaches. References. 5. Triarylmethanes and xanthenes. 5.1 Triarylmethanes. 5.2 Victoria blue series. 5.3 Structure and photoproperties in triarylmethanes -- extending the long-wavelength absorption. 5.4 Synthesis. 5.5 Xanthene derivatives. 5.6 Biological uses. 5.7 Rhodamines. 5.8 Rosamines. 5.9 Pyrylium compounds. 5.10 Pyronines. References. 6. Porphyrins. 6.1 Central metals. 6.2 Meso compounds. 6.3 Amino derivatives. 6.4 Hetero-porphyrins. 6.5 Chlorins. 6.6 Benzoporphyrin derivative. 6.7 Temoporfin. 6.8 Tookad. 6.9 Purpurins. 6.10 Texaphyrins. 6.11 Porphycenes. 6.12 5-Aminolaevulinic acid. 6.13 Esters. References. 7. Phthalocyanines. 7.1 General features. 7.2 Phthalocyanine synthesis. 7.3 Photosens. 7.4 Naphthalocyanines. 7.5 Hetero-fused systems. 7.6 Silicon derivatives. 7.7 Photoantimicrobial activity. References. 8. Cyanines. 8.1 Synthesis. 8.2
... mehr
Merocyanine 540. 8.3 N,N'-bis(2-ethyl-l,3-dioxolane)kryptocyanine. 8.4 Indocyanine green. 8.5 Structural improvement. 8.6 Squaric and croconic acid derivatives. 8.7 Functional cyanines. References. 9. Natural product photosensitisers. 9.1 Condensed aromatic pigments: perylene- and phenanthroperylenequinones. 9.2 Hypericin-type photosensitisers. 9.3 Hypocrellins. 9.4 Anthraquinones. 9.5 Psoralens (furocoumarins). 9.6 Isoquinoline alkaloid photosensitisers. 9.7 Riboflavin. 9.8 Terthiophenes. References. PART 3: APPLICATIONS. 10. PDT in oncology. 10.1 Photosensitisers for use in photodynamic therapy. 10.2 Indications for photodynamic therapy. 10.3 Skin. 10.4 Head and neck. 10.5 Gastrointestinal tract. 10.6 Breast. 10.7 Lung. 10.8 Genitourinary tract and prostate. 10.9 Brain. 10.10 Haematological disease (leukaemia and lymphoma). 10.11 Targeting/formulation. 10.12 Liposomes. 10.13 Biomolecular conjugation. 10.14 Dendrimers. 10.15 Nanoparticles. 10.16 Magnetic targeting. 10.17 Light in photodynamic therapy. References. 11. Antimicrobial -- PACT. 11.1 Antimicrobial and photoantimicrobial action. 11.2 Applications. 11.3 Blood. 11.4 Thionin/light + low-dose UVB for the decontamination of platelet concentrates. 11.5 The cellular problem. 11.6 A role for photodynamic antimicrobial chemotherapy in tropical medicine? References. 12. Non-oncological applications. 12.1 Age-related macular degeneration. 12.2 Atherosclerosis. 12.3 Endometreosis. 12.4 Port wine stain. 12.5 Arthritis and autoimmune disorders. 12.6 Photodynamic diagnosis. 12.7 Photocytotoxics and photochemical internalisation. References. Index.
... weniger
Autoren-Porträt von Mark Wainwright
Dr Mark Wainwright, School of Pharmacy and Chemistry, Liverpool John Moores University, UK.
Bibliographische Angaben
- Autor: Mark Wainwright
- 2009, 1. Auflage, 296 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 0470744944
- ISBN-13: 9780470744949
- Erscheinungsdatum: 25.03.2009
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