Regulation of Organelle and Cell Compartment Signaling (PDF)

Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.

Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

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"In order to keep researchers and students up to date on developments in the field, 55 articles were selected and reprinted from the 2008 second edition of the ‘Handbook of Cell Signaling’ on the transcriptional regulation and the function of nuclei and other subcellular organelles in signaling activities. After an overview, they cover nuclear signaling in transcription, chromatic remodeling, and stress response; signaling to and from intracellular compartments; and cell cycle and cell death signaling. This is one of four volumes of such reprints, called the Cell Signaling Collection."--Reference and Research Book News