Sample Preparation for Hyphenated Analytical Techniques (PDF)

Linking "standard" but often mutually incompatible
analytical techniques - so called hyphenation -
generally leads to enhanced analytical performance, so hyphenated
techniques are widely used in areas where samples are presented in
complex matrices, eg environmental, pharmaceutical and biochemical
analysis. With these hyphenated techniques, sample preparation is
often the most time-consuming step in analysis, particularly where
compounds are present in low concentration, and it has a huge
influence on the quality of the analytical results. Sample
preparation is still not given the importance it deserves, however.

The purpose of this book is to demonstrate the sample
preparation chemistry that has enabled the present sensitivity,
specificity and high throughput available across a range of
hyphenated analytical techniques, and to illustrate the successful
utilization of existing sample preparation methodologies in various
analytical applications. It identifies the problems in biology,
environmental science and pharmaceutical chemistry that require new
ideas in chemistry and provides considered opinion on those newer
techniques that may address these problems. By dealing with wider
issues than is generally found in review papers, this book will
provide analytical chemists with insights that are not available by
searching the literature for papers on a specific topic.