Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases / Springer Theses (PDF)

Name: Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases / Springer Theses
Brand: Springer-Verlag GmbH
SKU: 80736173
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(Sprache: Englisch)

Autor: Matthew Jenner

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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases / Springer Theses, Matthew Jenner

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This thesis reports studies on the
substrate specificity of crucial ketosynthase (KS) domains from trans-AT
Polyketide Synthases (PKSs). Using a combination of electrospray
ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC)
substrate mimics, Matthew Jenner has successfully studied the specificity of a
range of KS domains from the bacillaene and psymberin PKSs with regard to the
initial acylation step of KS-catalysis. The findings in this thesis provide
important insights into mechanisms of KS specificity and show that mutagenesis can
be used to expand the repertoire of acceptable substrates for future PKS
engineering. The documentation of this research is a useful reference and
guideline for students starting a PhD in this field.

Autoren-Porträt von Matthew Jenner

Matthew Jenner graduated with a BSc (Hons) in Biochemistry from the University of Nottingham in 2010. He conducted the work presented in this Thesis under the supervision of Dr. Neil Oldham following a fruitful final year undergraduate project, and obtained a DPhil in Chemistry in 2015 from the University of Nottingham. He is currently conducting postdoctoral research at the University of Warwick with Prof. Greg Challis.