Strategies for Organic Drug Synthesis and Design (PDF)

Preface 1. PROSTAGLANDINS, PEPTIDOMIMETIC COMPOUNDS, AND RETINOIDS. 1.1 Prostaglandnis. 1.2 Peptidonimetic Compounds. 1.3 Retinoids. 1.4 A Miscellaneous Drug. References. 2. DRUG BASED ON A SUBSTITUTED BENZENE RING 2.1 Arylethanolamines. 2.2 Aryloxypropanolamines. 2.3 Arylsulfonic Acid Derivatives. 2.4 Arylacetic and Arylpropionic Acids. 3. INDENES, NAPHTHALENES AND OTHER POLYCYCLIC AROMATIC COMPOUNDS 3.1 Indenes. 3.2 Naphthalenes. 3.3 Partly Reduced Naphthalenes. 3.4 Tricyclic Compounds. References. 4. STEROIDS; PART 1: ESTRANES, GONANES, AND ANDROSTANES 4.1 Introduction. 4.2 Steroid Starting Materials. 4.3 Estranes. 4.4 Gonanes, the 19-nor Steroids. 4.5 Androstanes. References. 5. STEROIDS; PART 2: COMPOUNDS RELATED TO PROGESTERONE, CORTISONE, AND CHOLESTEROL. 5.1 Introduction. 5.2 Progestins. 5.3 Corticosteroids. 5.4 Compounds Derived from Cholesterol. References. 6. NONSTEROIDAL SEX HORMONES AND THEIR ANTAGONISTS 6.1 Introduction. 6.2 Estrogens. References. 7. OPIOID ANAlGESICS 7.1 Introduction 7.2 Drugs Derived from Morphine. 7.3 Compounds Prepared from Thebaine. 7.4 Morphinans. 7.5 Benzomorphans. 7.6 Analgesics Based on Nonfused Piperidines. References. 8. DRUGS BASED ON FIVE-MEMBERED HETEROCYCLES 8.1 Introduction. 8.2 Rings that Contain One Heteroatom. 8.3 Rings that Contain Two Heteroatoms. 8.4 Rings that Contains Three or More Heteroatoms. References. 9. DRUGS BASED ON SIX-MEMBERED HETEROCYCLES. 9.1 Rings that Contain One Heteroatom. 9.2 Rings that Contain Two Heteroatoms. 9.3 Rings Containing Three Heteroatoms: The Triazines. References. 10. FIVE-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING. 10.1 Compounds that Contain One Heteroatom. 10.2 Compounds that Contain Two Heteroatoms. 10.3 Compounds that Contain Three Heteroatoms. References. 11. SIX-MEMBERED HETEROCYCLES FUSED TO A BENZENE RING 11.1 Compounds that Contain One Heteroatom. 11.2 Compounds that Contain Two Heteroatoms. 11.3 Compounds that Contain Three Heteroatoms. References. 12. SEVEN-MEMBERED

Daniel Lednicer, PhD, is the acclaimed author of several books on drug synthesis and discovery. His career has been devoted to the search for new therapeutic agents. Dr. Lednicer spent two decades at the bench as a chemist at the Upjohn Company. He has also served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute.

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