Superbases for Organic Synthesis (PDF)
Guanidines, Amidines, Phosphazenes and Related Organocatalysts
(Sprache: Englisch)
Guanidines, amidines and phosphazenes have been attracting
attention in organic synthesis due to their potential functionality
resulting from their extremely strong basicity. They are also
promising catalysts because of their potential for easy...
attention in organic synthesis due to their potential functionality
resulting from their extremely strong basicity. They are also
promising catalysts because of their potential for easy...
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Guanidines, amidines and phosphazenes have been attracting
attention in organic synthesis due to their potential functionality
resulting from their extremely strong basicity. They are also
promising catalysts because of their potential for easy molecular
modification, possible recyclability, and reduced or zero toxicity.
Importantly, these molecules can be derived as natural products
- valuable as scientists move towards "sustainable
chemistry", where reagents and catalysts are derived from
biomaterial sources.
Superbases for Organic Synthesis is an essential guide to
these important molecules for preparative organic synthesis. Topics
covered include the following aspects:
* an introduction to organosuperbases
* physicochemical properties of organic superbases
* amidines and guanidines in organic synthesis
* phosphazene: preparation, reaction and catalytic role
* polymer-supported organosuperbases
* application of organosuperbases to total synthesis
* related organocatalysts: proton sponges and urea
derivatives
* amidines and guanidines in natural products and medicines
Superbases for Organic Synthesis is a comprehensive,
authoritative and up-to-date guide to these important reagents for
organic chemists, drug discovery researchers and those interested
in the chemistry of natural products.
attention in organic synthesis due to their potential functionality
resulting from their extremely strong basicity. They are also
promising catalysts because of their potential for easy molecular
modification, possible recyclability, and reduced or zero toxicity.
Importantly, these molecules can be derived as natural products
- valuable as scientists move towards "sustainable
chemistry", where reagents and catalysts are derived from
biomaterial sources.
Superbases for Organic Synthesis is an essential guide to
these important molecules for preparative organic synthesis. Topics
covered include the following aspects:
* an introduction to organosuperbases
* physicochemical properties of organic superbases
* amidines and guanidines in organic synthesis
* phosphazene: preparation, reaction and catalytic role
* polymer-supported organosuperbases
* application of organosuperbases to total synthesis
* related organocatalysts: proton sponges and urea
derivatives
* amidines and guanidines in natural products and medicines
Superbases for Organic Synthesis is a comprehensive,
authoritative and up-to-date guide to these important reagents for
organic chemists, drug discovery researchers and those interested
in the chemistry of natural products.
Inhaltsverzeichnis zu „Superbases for Organic Synthesis (PDF)“
Preface. Acknowledgements. List of Contributors. 1. General Aspects of Organosuperbases (Tsutomu Ishikawa). 2. Physicochemical Properties of Organic Superbases (Davor Margetic). 2.1 Introduction. 2.2 Proton sponges. 2.3 Amidines. 2.4 Guanidines. 2.5 Phosphazenes. 2.6 Guanidinophosphazenes. 2.7 Other Phosphorus Containing Superbases: Verkade's Proazaphosphatranes. 2.8 Theoretical Methods. 2.9 Concluding Remarks. References. 3. Amidines in Organic Synthesis (Tsutomu Ishikawa and Takuya Kumamoto). 3.1 Introduction. 3.2 Preparation of Amidine. 3.3 Application of Amidines to Organic Synthesis. 3.4 Amidinium Salt: Design and Synthesis. 3.5 Concluding Remarks. References. 4. Guanidines in Organic Synthesis (Tsutomu Ishikawa). 4.1. Introduction. 4.2. Preparation of Chiral Guanidines. 4.3 Guanidines as Synthetic Tools. 4.4 Guanidinium Salt. 4.5 Concluding Remarks. References. 5. Phosphazene: Preparation, Reaction and Catalytic Role (Yoshinori Kondo). 5.1 Introduction. 5.2 Deprotonative Transformations Using Stoichiometric Phosphazenes. 5.3 Transformation Using Phosphazene Catalyst. 5.4 Proazaphosphatrane Base (Verkade's Base). 5.5 Concluding Remarks. References. 6. Polymer-supported Organosuperbases (Hiyoshizo Kotsuki). 6.1 Introduction. 6.2 Acylation reactions. 6.3 Alkylation Reactions. 6.4 Heterocyclization. 6.5 Miscellaneous. 6.6 Concluding Remarks. References. 7. Application of Organosuperbases to Total Synthesis (Kazuo Nagasawa). 7.1 Introduction. 7.2 Carbon-carbon bond-forming reactions. 7.3 Deprotection. 7.4 Elimination. 7.5 Ether synthesis. 7.6 Heteroatom conjugate addition. 7.7 Isomerization. 7.8 Concluding Remarks. References. 8. Related Organocatalysts (1): Proton Sponge (Kazuo Nagasawa). 8.1 Introduction. 8.2 Alkylation and Hetero Michael reaction. 8.3 Amide formation. 8.4 Carbon-carbon bond-forming reaction. 8.5 Palladium-catalyzed reaction. 8.6 Concluding Remarks. References. 9. Related Organocatalysts (2): Urea Derivatives (Waka Nakanishi). 9.1 Introduction.
... mehr
9.2 Bisphenol as Organoacid Catalyst. 9.3 Urea and Thiourea as Achiral Catalysts. 9.4 Urea and Thiourea as Chiral Catalyst. 9.5 Concluding Remarks. References. 10. Amidines and Guanidines in Natural Products and Medicines (Takuya Kumamoto). 10.1 Introduction. 10.2 Natural Amidine Derivatives. 10.3 Natural Guanidine Derivatives. 10.4 Medicinal Amidine and Guanidine Derivatives. References. 11. Perspective (Tsutomu Ishikawa and Davor Margetic).
... weniger
Autoren-Porträt von Tsutomu Ishikawa
Professor Tsutomu Ishikawa, Graduate School of Pharmaceutical Sciences, Chiba University, JapanProfessor Ishikawa leads a laboratory of researchers at Chiba University in the fields of drug-oriented organic chemistry, natural product chemistry, guanidine-based organic reactions, synthetic studies on aziridines, and the preparation of new polymer-supported reagents. He has published 30 papers, including "Guanidines in Organic Synthesis" - one of the top 5 most downloaded papers of 2006 in the leading organic chemistry journal Synthesis.
Bibliographische Angaben
- Autor: Tsutomu Ishikawa
- 2009, 1. Auflage, 336 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 0470740868
- ISBN-13: 9780470740866
- Erscheinungsdatum: 26.01.2009
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