Targeting the DNA Damage Response for Cancer Therapy / Cancer Treatment and Research Bd.186 (PDF)

Dr. Timothy A. Yap is a Medical Oncology Physician-Scientist and tenured Professor based at the University of Texas MD Anderson Cancer Center. He is a Professor in the Department for Investigational Cancer Therapeutics (Phase I Program), and the Department of Thoracic/Head and Neck Medical Oncology.
Dr. Yap is Vice President and Head of Clinical Development in the Therapeutics Discovery Division, a drug discovery biopharmaceutical division where drug discovery and clinical translation are seamlessly integrated.
He is also the Associate Director of Translational Research in the Institute for Personalized Cancer Therapy, which is an integrated research and clinical trials program aimed at implementing personalized cancer therapy and improving patient outcomes.
Dr. Yap's main research focuses on the first-in-human and combinatorial development of molecularly targeted agents and immunotherapies, and their acceleration through clinical studies using novel predictive and pharmacodynamic biomarkers. His main interests include the targeting of the DNA damage response (DDR) with novel therapeutics through clinical trials and translational studies. These including targets such as ATR, PARP1, WEE1, POLQ, USP1, PARG, CHK1, ATM and DNA-PK inhibitors, next generation CDK4 and CDK2-selective inhibitors, WRN inhibitors, SMARCA2 inhibitors, YAP/TEAD inhibitors, as well as the development of novel immunotherapeutics.
Prior to his current position, Dr. Yap was a Consultant Medical Oncologist at The Royal Marsden Hospital in London, UK and National Institute for Health Research BRC Clinician Scientist at The Institute of Cancer Research, London, UK.
Dr. Shapiro currently serves as Senior Vice President, Developmental Therapeutics, at the Dana-Farber Cancer Institute (DFCI). In this role, he co-leads the Developmental Therapeutics Program for the Dana-Farber/Harvard Cancer Center (DF/HCC) as well as the Cancer Center's activities in the NCI-Cancer Therapy Evaluation Program