The Mizoroki-Heck Reaction (PDF)

Exploring the importance of Richard F. Heck's carbon coupling
reaction, this book highlights the subject of the 2010 Nobel Prize
in Chemistry for palladium-catalyzed cross couplings in organic
synthesis, and includes a foreword from Nobel Prize winner Richard
F. Heck.

The Mizoroki-Heck reaction is a palladium-catalyzed
carbon-carbon bond forming process which is widely used in
organic and organometallic synthesis. It has seen increasing use in
the past decade as chemists look for strategies enabling the
controlled construction of complex carbon skeletons. The
Mizoroki-Heck Reaction is the first dedicated volume on this
important reaction, including topics on:

* mechanisms of the Mizoroki-Heck reaction

* intermolecular Mizoroki-Heck reactions

* focus on regioselectivity and product outcome in organic
synthesis

* waste-minimized Mizoroki-Heck reactions

* intramolecular Mizoroki-Heck reactions

* formation of heterocycles

* chelation-controlled Mizoroki-Heck reactions

* the Mizoroki-Heck reaction in domino processes

* oxidative heck-type reactions (Fujiwara-Moritani
reactions)

* Mizoroki-Heck reactions with metals other than palladium

* ligand design for intermolecular asymmetric Mizoroki-Heck
reactions

* intramolecular enantioselective Mizoroki-Heck reactions

* desymmetrizing Mizoroki-Heck reactions

* applications in combinatorial and solid phase syntheses, and
the development of modern solvent systems and reaction
techniques

* the asymmetric intramolecular Mizoroki-Heck reaction in natural
product total synthesis

Several chapters are devoted to asymmetric Heck reactions with
particular focus on the construction of otherwise
difficult-to-obtain sterically congested tertiary and quaternary
carbons. Industrial and academic applications are highlighted in
the final section. The Mizoroki-Heck Reaction will find a
place on the bookshelves of any organic or organometallic
chemist.

"I am convinced that this book will rapidly become the
most important reference text for research chemists in academia and
industry who seek orientation in the rapidly growing and -
for the layman - confusing field described as the
"'Mizoroki-Heck reaction'."
(Synthesis, March 2010)