Transcriptional Control of Cell Growth / Current Topics in Microbiology and Immunology Bd.208 (PDF)
The E2F Gene Family
(Sprache: Englisch)
It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the...
sofort als Download lieferbar
eBook (pdf)
98.99 €
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
Produktdetails
Produktinformationen zu „Transcriptional Control of Cell Growth / Current Topics in Microbiology and Immunology Bd.208 (PDF)“
It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor mally control this decision can lead to cancer, cell death, or loss of differentiated cellular phenotypes. The identification of the E2F gene family of transcription factors has allowed a more complete understanding of how the cell maintains an appropri ate proliferative state. This volume provides an up-to-date ac count of present reports concerning E2F as well as a framework for future investigations. E2F activity requires heterodimerization of two partners. Either partner can be one of several different transcription factors; E2Fl, E2F2, E2F3, E2F4, or E2F5 can heterodimerize with either DPl or DP2. Cellular promoters whose E2F sites mediate a link between transcription and proliferation drive genes whose products are required for DNA synthesis and genes that encode regulators of cell growth. A detailed analY$is of the role that E2F family members play in transcription from these promoters is presented in the chapter by J. E. SLANSKY and P. J. FARNHAM.
Bibliographische Angaben
- 2012, 1996, 141 Seiten, Englisch
- Herausgegeben: Peggy J. Farnham
- Verlag: Springer Berlin Heidelberg
- ISBN-10: 3642799108
- ISBN-13: 9783642799105
- Erscheinungsdatum: 06.12.2012
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: PDF
- Größe: 22 MB
- Ohne Kopierschutz
- Vorlesefunktion
Sprache:
Englisch
Kommentar zu "Transcriptional Control of Cell Growth / Current Topics in Microbiology and Immunology Bd.208"
Schreiben Sie einen Kommentar zu "Transcriptional Control of Cell Growth / Current Topics in Microbiology and Immunology Bd.208".
Kommentar verfassen