Translational Research and Discovery in Gastroenterology (ePub)

Translational Gastroenterology: Organogenesis to Disease
bridges the gap between basic and clinical research by providing
information on GI (gastrointestinal) organ development discovered
through scientific inquiry, alongside clinical observations of
acquired and congenital abnormalities. Paired chapters, written
from basic science and clinical viewpoints, review the major
biological pathways and molecules at work in organ ontogeny and
disease. In addition to a comprehensive survey of GI organ
development and pathologies, the book also highlights model
organisms and new areas of research, with chapters devoted to
recent advances in the field of GI stem cell biology, and the
potential for tissue engineering of GI organs.

The topics covered provide a unique window onto current activity
in the field of gastroenterology, fostering enhanced knowledge for
developmental biologists as well as for clinical practitioners.

Notable features include the following:

* Basic science chapters review the molecular and cellular
pathways of GI organ development alongside clinical chapters
examining organ-based diseases, closing the gap between the bench
and the clinic.

* Derivative organs - esophagus, stomach, pylorus,
small intestine, colon, liver, and pancreas -as well as
tissues such as serosa and enteric nervous system that are common
to multiple GI organs.

* Chapters detailing the use of model organisms -
Drosophila, sea urchin, zebrafish, C. elegans, Xenopus - for
basic discovery studies are included.

* Chapters on GI stem cells and the potential for tissue
engineering of the GI organs provide a view to the future of
research and therapy in these organs.