Vaccine Efficacy Evaluation (ePub)

Name: Vaccine Efficacy Evaluation
Brand: Taylor & Francis
SKU: 142881654
Price: 61.70 EUR
Availability: OnlineOnly

The Gnotobiotic Pig Model (Sprache: Englisch)

Autor: Lijuan Yuan

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Vaccine Efficacy Evaluation, Lijuan Yuan

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This book provides detailed information on establishing gnobiotic pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.

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Autoren-Porträt von Lijuan Yuan

Lijuan Yuan is a Professor of Virology and Immunology in the Virginia-Maryland Vet Med's Department of Biomedical Sciences & Pathobiology. Dr. Yuan studies the interactions between enteric viruses and the host immune system. Her lab's research interests are focused on the pathogenesis and innate and adaptive immune responses induced by enteric viruses, especially noroviruses and rotaviruses, and on the development of safer and more effective vaccines as well as passive immune prophylaxis and therapeutics against viral gastroenteritis. These studies utilize wild-type, gene knock-out, and human gut microbiota transplanted gnotobiotic pig models of human rotavirus and norovirus infection and diseases and cell culture model of rotavirus infection. Currently, the Yuan lab is evaluating the immunogenicity and protective efficacy of several candidate novel rotavirus and norovirus vaccines and engineered probiotic yeast Saccharomyces boulardii secreting multi-specific single-domain antibodies as novel prophylaxis against both noroviruses and Clostridioides difficile toxins. See: https://vetmed.vt.edu/people/faculty/yuan-lijuan.html