Adhesion GPCRs

The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution.- 7TM-Cadherins: Developmental Roles and Future Challenges.- Latrophilin Signalling in Tissue Polarity and Morphogenesis.- GPS Proteolytic Cleavage of Adhesion-GPCRs.- The Latrophilins, "Split-Personality" Receptors.- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals.- Adhesion-GPCRs in the CNS.- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression.- Adhesion-GPCRs in Tumorigenesis.- Immunity and Adhesion-GPCRs.- CD97 in Leukocyte Trafficking.- The Role of CD97 in Regulating Adaptive T-Cell Responses.- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation.- Signal Transduction Mediated through Adhesion-GPCRs.- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1.- Adhesion-GPCRs in the Male Reproductive Tract.

Simon Yona, PhD, graduated from Kings College, University London with a BSc in Physiology and a MSc in Pharmacology, before completing a PhD with Prof. R.J. Flower FRS and Prof. M. Perretti, at St. Bartholomew's Hospital, University of London. Following his doctorate Simon took up a Postdoctoral Research position with Prof. S. Gordon FRS, at the Sir William Dunn School of Pathology, University of Oxford, where he investigated the roles and functions of the leukocyte restricted adhesion GPCRs. Dr. Yona moved from Oxford to join the group of Prof. S. Jung, at the Weizmann Institute of Science, Rehovot, when he was awarded a Federation of European Biochemical Societies, International Fellowship. Currently he is investigating the developmental profile of mononuclear phagocytes in a number of pathologies. Martin Stacey, DPhil (Oxon), graduated from Hertford College, University of Oxford with an MBiochem before completing a DPhil in the laboratory of Prof. S. Gordon FRS. He continued working at the Sir William Dunn School of Pathology for a number of years where he cloned and characterized leukocyte adhesion GPCRs and demonstrated the existence of their cell surface ligands. More recently, Dr. Stacey has been appointed as a Lecturer of Immunology, at the University of Leeds where his laboratory focuses on adhesion GPCRs and role of myeloid cells in human disease.