Advances in Synthetic Chemistry

PrefacePART I: Innovative Processes in Organic ChemistryN-HYDROXY DERIVATIVES: KEY ORGANOCATALYSTS FOR THE SELECTIVE FREE RADICAL AEROBIC OXIDATION OF ORGANIC COMPOUNDSIntroductionGeneral Reactivity of N-Hydroxy DerivativesAerobic Oxidation Catalyzed by N-Hydroxy AminesAerobic Oxidation Catalyzed by N-Hydroxy AmidesAerobic Oxidation Catalyzed by N-Hydroxy ImidesConclusionsGOLD-CATALYZED INTRA- AND INTERMOLECULAR CYCLOADDITIONS OF PUSH-PULL DIENYNESIntroductionGold-Catalyzed Enyne CycloisomerizationsGold-Catalyzed Intermolecular CycloadditionsConclusions and Future PerspectivesN-HETEROCYCLIC CARBENES IN COPPER-CATALYZED REACTIONSIntroductionPreparation of NHC-Containing Copper ComplexesMain Applications of [(NHC)Cu] Complexes in CatalysisCopper Hydride-Mediated Reactions[3+2] Cycloadditions of Azides and AlkynesConcluding RemarksSUPPORTED ORGANOCATALYSTS AS A POWERFUL TOOL IN ORGANIC SYNTHESISIntroductionL-Proline and its Derivatives on Ionic Liquid-Modified Silica GelsPolystyrene-Supported Proline as a Versatile and Recyclable OrganocatalystProlinamide-Supported Polystyrenes as Highly Stereoselective and Recyclable Organocalysts for the Aldol ReactionOutlook and Future PerspectivesTHE COMPLEX-INDUCED PROXIMITY EFFECT IN ORGANOLITHIUM CHEMISTRY AND ITS IMPORTANCE IN THE LITHIATION OF TERTIARY AMINESIntroductionState of the ArtLatest DevelopmentsConclusions and OutlookPART II: Predictive Tools in Organic Chemical ReactionsDOUBLE HYDROGEN BONDING IN ASYMMETRIC ORGANOCATALYSIS: A MECHANISTIC PERSPECTIVEIntroductionDiols and Amidoalcohols(Thio)ureasPhosphoric AcidsOther CatalystsConclusions and OutlookDYNAMIC COVALENT CAPTURE: A SENSITIVE TOOL FOR DETECTING MOLECULAR INTERACTIONSIntroductionHydrogen Bond-Driven Self-Assembly in Aqueous SolutionMeasuring Stability and Order in Biological StructuresDrug DiscoveryCatalyst DiscoveryThe Analysis of Complex Chemical SystemsPerspectivePART III: Chemical Reactions, Sustainable Processes, and EnvironmentFURFURAL AND

Bruno Pignataro, born in Bologna in 1972, is Professor of Physical Chemistry at the University of Palermo. He received his degree in chemistry in 1995 from the University of Catania and his PhD in materials science five years later. He has helped establish a wide network of international collaborations and organized more than 10 meetings at national and international level, including coordinating the Young Chemists Group of the Italian Chemical Society and chairing the first editions of the European Young Chemist Award. He is a referee for several leading chemistry and materials journals, has more than 70 scientific publications and some 90 conference communications to his name, along with several invited lectures. Professor Pignataro's research interests focus on the related fields of the physical chemistry of molecular surfaces and soft nanotechnologies.