Applications of Microfluidic Systems in Biology and Medicine

Chapter 1: Acoustofluidic blood component sample preparation and processing in medical applications

Maria Antfolk and Thomas Laurell

Chapter 2: Microfluidic technologies and platforms for protein crystallography Masatoshi Maeki and Manabu Tokeshi

Chapter 3: Application of Sers-based Microfluidics for in Vitro Diagnostics Jinhyeok Jeon, Namhyun Choi, Joung-Il Moon, Hao Chen and Jaebum Choo

Chapter 4: Miniaturized Electrochemical Sensors to Facilitate Liquid Biopsy for Detection of Circulating Tumor Markers Yi-Ge Zhou, Leyla Kermanshah, Libing Zhang and Reza M. Mohamadi

Chapter 5: Spiral Inertial Microfluidics for Cell Separation and Biomedical Applications Ning Liu, Chayakorn Petchakup, Hui Min Tay, King Ho Holden Li and Han Wei Hou

Chapter 6: Worms on a Chip Han-Sheng Chuang, Wen-Hui Wang, Chang-Shi Chen

Chapter 7: Microfluidic devices for gamete processing and analysis, fertilization and embryo culture and characterization Séverine Le Gac, Verena Nordhoff, Bastien Venzac

Chapter 8: Microfluidic organs-on-chips to reconstitute cellular microenvironments

Yu-suke Torisawa

Chapter 9: In vitro tissue construction for organ-on-a-chip applications Yuya Morimoto, Nobuhito Mori and Shoji Takeuchi

Chapter 10: Nanobiodevices for Cancer Diagnostics and Stem Cell Therapeutics

D. Onoshima, H. Yukawa and Y. Baba

Chapter 11: Nanopore Device for Single-Molecule Sensing Method and Its Application

Masateru Taniguchi and Takahito Ohshiro

Chapter 12: Paper Microfluidics for POC Testing in Low-resource Settings

Elain Fu Chapter 13: Paper-Based Microfluidics for Point-of-Care Medical Diagnostics

Kentaro Yamada and Daniel Citterio

Manabu Tokeshi is a professor in the Division of Applied Chemistry at Hokkaido University. He is also a visiting professor at the ImPACT Research Center for Advanced Nanobiodevices, the Innovative Research Center for Preventive Medical Engineering, and the Institute of Innovation for Future Society at Nagoya University. He received his Ph.D. degree from Kyushu University in 1997. Following his work as a research fellow of the Japan Society of Promotion of Science at The University of Tokyo, he worked at the Kanagawa Academy of Science and Technology as a research staff member (1998¿1999), a group subleader (1999¿2003), and a group leader (2003¿2004). He also served at the Institute of Microchemistry Technology Co. Ltd. as president (2004¿2005) and at Nagoya University as an associate professor (2005¿2011). In 2011, Dr. Tokeshi was at the Karolinska Institutet in Sweden as a visiting researcher, after which joined Hokkaido University as a professor. His honors include the Outstanding Researcher Award on Chemistry and Micro-Nano Systems from the Society for Chemistry and Micro-Nano Systems (2007), the Pioneers in Miniaturisation Prize from the Lab on a Chip (The Royal Society of Chemistry)/Corning Inc. (2007), and the Masao Horiba Award from HORIBA, Ltd. (2011). His research interests are in the development of micro- and nano-systems for chemical, biochemical, and clinical applications. Contributors: Thomas Laurell, Lund University Manabu Tokeshi, Hokkaido University Jaebum Choo, Chung-Ang University Reza M. Mohamadi, University of Toronto Hou Han Wei, Nanyang Technological University Han-Sheng Chung, National Cheng Kung University Severine Le Gac, University of Twente Yu-suke Torisawa, Kyoto University Shoji Takeuchi, The University of Tokyo Yoshinobu Baba, Nagoya University Masateru Taniguchi, Osaka University Elain Fu, Oregon State University Citterio Daniel, Keio University