Biological Reactive Intermediates Vi
Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases
(Sprache: Englisch)
Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require...
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Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which products of enzymatic reactions proceed to undergo further reactions non enzymatically with cellular macromolecules. The results can often be seen as toxic or carcinogenic responses. The chemicals that initiate these reactions are termed "biological reactive intermediates. " The International Symposia on Biological Reactive Intermediates (BRI) began in 1975 at the University of Turku, Finland and have since convened at the University of Surrey, Guildford, The United Kingdom (1980), the University of Maryland, College Park, Maryland (1985), the University of Arizona, Tucson, Arizona (1990), the GSF Forschungszentrum and Technical University of Munich (1995) and, most recently, at the Universite Rene Descartes, Paris, France (2000). The Symposium was organized by an International Planning Committee co-chaired by P. Dansette (Paris, France) and TJ. Monks (Austin, Texas). The committee included: P. H. Beaune (Paris, France), M. Deaforge (Saclay, France), G. P. Gervasi (Pisa, Italy), G. G. Gibson (Guildford, UK), H. Greim (Munich, Germany), DJ. Jollow (Charleston, South Carolina), P. Moldeus (Sodertalje, Sweden), I. G. Sipes (Tucson, Arizona), R. Snyder PJ. van Bladderen (Zeist, The Netherlands). They were (Piscataway, New Jersey), and assisted by an International Scientific Program Advisory Committee which included: TJ.
Inhaltsverzeichnis zu „Biological Reactive Intermediates Vi “
- Keynote Presentation; S. Orrenius, et al. Session I.
- Structure Activity Relationships for the Chemical Behaviour and Toxicity of Electrophilic Quinones/Quinone Methides; I.M.C.M. Rietjens, et al.
- Use of Structure-Activity Relationships for Probing Biochemical Mechanisms: Glutathione Transferase Zeta Conjugation of Haloacids; P.D. Swartz, A.M. Richard.
- Structure Toxicity Relationships - How Useful are They in Predicting Toxicities of New Drugs? S.D. Nelson.
Session II.
- Biological Reactive Intermediates in Drug Discovery and Development A Perspective from the Pharmaceutical Industry; T.A. Baillie, K. Kassahun.
- Bioactiviation of Toxicants by Cytochrome P450-Mediated Dehydrogenation Mechanisms; G.S. Yost.
- New Aspects of DNA Adduct Formation by the Carcinogens Crotonaldehyde and Acetaldehyde; S.S. Hecht, et al.
- Mechanisms of Ovotoxicity Induced by Environmental Chemicals: 4-Vinylcyclohexene Diepoxide as a Model Chemical; P.B. Hoyer, et al.
- Mutagenicity and Carcinogenicity of Biological Reactive Intermediate's Derived A `Non-Genotoxic' Carcinogen; S.S. Lau, et al.
- Reactive Metabolites of 1,3-Butadiene: DNA and Hemoglobin Adduct Formation and Potential Roles in Carcinogenicity; A.A. Elfarra, et al.
- Chemistry and Biological Activity of Novel Selenium Containing Compounds; J.N.M. Commandeur, et al.
- Formation and Fate of Reactive Intermediates of Haloalkanes, Haloalkenes, and alpha-Haloacids; M.W. Anders.
- Short Communications.
Session III.
- DNA Microarray Reveals Increased Expression of Thioredoxin Peroxidase in Thioredoxin-1 Transfected Cells and its Functional Consequences; B. Husbeck, et al.
- Reactive Nitrogen Species and Proteins: Biological Significance and Clinical Relevance; J.M. Souza, et al.
- Bicarbonate Enhances Nitration and Oxidation Reactions in Biological Systems-Role of Reactive Oxygen and Nitrogen Species; B. Kalyanaraman,
... mehr
et al.
- Nitric Oxide and Peroxynitrite in Ozone-Induced Lung Injury; D.L. Laskin, et al.
- Antioxidant Reactions of Green Tea Catechins and Soy Isoflavones; D.C. Liebler, et al.
- Short Communications.
Session IV.
- Chromosome Damage From Biological Reactive Intermediates of Benzene and 1,3-Butadiene in Leukemia; M.T. Smith. hOGG1
- Gene Alterations in Human Clear Cell Carcinomas of the Kidney: Effect of Single Mutations in hOGG1
- Gene on Substrate Specificity of the hOgg1 Protein; M. Audebert, et al.
- The Antitumor Agent Ecteinascidin 743: Characterization of its Covalent DNA Adducts and Chemical Stability; L.H. Hurley, M. Zewail-Foote.
- Design of DNA Damaging Agents that Hijack Transcription Factors and Block DNA Repair; J.M. Essigmann, et al.
- Short Communications.
Session V.
- Are Blood-Brain Interfaces Efficient in Protecting the Brain From Reactive Molecules? J.-F. Ghersi-Egea, et al.
- The Roles of P-Glycoprotein and MRP1 in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; A.H. Schinkel.
- Are Dopamine, Norepinephrine, and Serotonin precursors of Biologically Reactive Intermediates Involved in the Pathogenesis of Neurodegenerative Brain Disorders? G. Dryhurst.
- Serotonergic Neurotoxicity of Methylenedioxyamphetamine and Methylenedioxymetamphetamine; T.J. Monks, et al.
Session VI.
- Caspase Cascades in Chemically-Induced Apoptosis; S.B. Bratton, G.M. Cohen.
- Spermatogenesis by Sisyphus: Proliferating Stem Germ Cells Fail to Repopulate the Testis After `Irreversible' Injury; K. Boekelheide, H.A. Schoenfeld.
- The Interaction of 1,4-Benzoquinone, A Bioreactive Intermediate of Benzene, With Three Proteins Essential for Differentiation? Maturation of the Mouse Myeloid Stem Cell; G.F. Kalf, et al.
- Hematopoietic Stem and Progenitor Cells as Targets for Biological Reactive Intermediates; R.D. Irons, et al.
Session VII.
- Tobacco Toxicology Revisited; H. Witschi.
- Functional Genomics of Oxidant-Induced Lung Injury; G.D. Leikauf, et al.
- Mitochondrial-derived Oxidants and Quartz Activation of Chemokine Gene Expression; K.E. Driscoll, et al.
- Quinoids as Reactive Intermediates in Estrogen Carcinogenesis; J.L. Bolton, M. Chang.
Session VIII.
- Inhibition of Carcinogenesis and Toxicity by Dietary Constituents; C.S. Yang.
- Modelling the Responses to Biological Reactive Intermediates: Establishing the Borderlines of Risk; P.J. van Bladeren, et al.
- Interindividual Differences in Response to Chemoprotection Against Aflatoxin-Induced Hepatocarcinogenesis: Implifications for Human Biotransformation Enzyme Polymorphisms; D.L. Eaton, et al.
- Sequestration of Biological Reactive Intermediates by Trapping as Covalent Enzyme-Intermediate Complex; F. Oesch, et al.
- Chemoprotection and Interindividual Differences in Response to Biological Reactive Intermediates; R. Thier.
- Oxidative Stress, Glucose-6-Phosphate Dehydrogenase and the Red Cell; D.J. Jollow, D.C. McMillan.
- Short Communications.
Session IX.
- Reactive Intermediates in Biological Systems: What Have we Learned and Where are we Going? F.P. Guengerich, et al.
- Short Communications.
Workshop on Utilization
of Covalent Binding Data in Risk Assessment.
Session I: Covalent
binding to Proteins. The Role of Toxicological Science in Risk Assessment and Risk Management; B.D. Goldstein.
- Oxidative Stress, Glucose-6-Phosphate Dehydrogenase and the Red Cell; D.J. Jollow, D.C. McMillan.
- Covalent Binding of Chemical Residues: Health Impact; A.Y.H. Lu.
- Identification of Hepatic Protein Targets of the Reactive Metabolites of the Non-Heptatotoxic Regioisomer of Acetaminophen, 3'-Hydroxyacetanilide, in the Mouse in vivo
- Using Two-Dimensional Gel Electrophoresis and Mass Spectrometry; Y. Qiu, et al.
Session II:
Covalent Binding to DNA. Exocyclic DNA Adducts as Secondary Markers for Oxidative Stress: Applications in Human Cancer Etiology and Risk Assessment; H. Bartsch, J. Nair.
- Dose Dependent Induction of DNA Adducts, Gene Mutations, and Cell Proliferation by the Antiandrogenic Drug Cyproterone Acetate in Rat Liver; T. Wolff, et al.
- Dose-Dependent Differences in the Profile of Mutations Induced by Carcinogenic (R,S,S,R)
- Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons; A.H. Conney, et al.
- Nucleic Acid Microarray Technology for Toxicology: Promise and Practicalities; D.E. Heck, et al.
- Use of Covalent Binding in Risk Assessment; H. Greim.
- Modulation Influence of p-Chloromercuribenzoate on Plasma Membrane Na+-Ca2+ Exchanger of the Secretory Cells of Chironomus
- Larvae Salivary Gland; N.V. Fedirko, et al.
- Pharmacokinetics of Benzene Following an Oral or Intradermal Dose in FVB and Tg.AC Mice; M.J. Hoffmann, et al.
- Preventive Effect of Selenium of T-2 Toxin Membrane Toxicity; S.A. Keshavarz, et al.
- The Potential Role of Topoisomerase II Inhibition in Hydroquinone-Induced Alterations in the Maturation of Mouse Myeloblasts; M.J. Hoffmann, et al.
- Metabolism of the Food Mutagen 2-Amino-3,8-Dimethylimidazo `4,5=f' Quinoxaline in Human Hepatocytes; S. Langouët, et al.
- Comparison of Two Methods: Culture of Vaginal Discharges and Indirect Fluorescent Antibody for Diagnosis of Listeria Monocytogenes in Pregnant Women; F.A. Nakhjavani, et al.
- Synthesis and Evaluation of New Male Contraceptives; H.R.S. Roodsarie, et al.
- Metabolism of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) in A/J Mouse Lung and Effect of Cigarette Smoke Exposure on In Vivo
- Metabolism to Biological Reactive Intermediates; A.R. Tricker, et al.
- Nitric Oxide and Peroxynitrite in Ozone-Induced Lung Injury; D.L. Laskin, et al.
- Antioxidant Reactions of Green Tea Catechins and Soy Isoflavones; D.C. Liebler, et al.
- Short Communications.
Session IV.
- Chromosome Damage From Biological Reactive Intermediates of Benzene and 1,3-Butadiene in Leukemia; M.T. Smith. hOGG1
- Gene Alterations in Human Clear Cell Carcinomas of the Kidney: Effect of Single Mutations in hOGG1
- Gene on Substrate Specificity of the hOgg1 Protein; M. Audebert, et al.
- The Antitumor Agent Ecteinascidin 743: Characterization of its Covalent DNA Adducts and Chemical Stability; L.H. Hurley, M. Zewail-Foote.
- Design of DNA Damaging Agents that Hijack Transcription Factors and Block DNA Repair; J.M. Essigmann, et al.
- Short Communications.
Session V.
- Are Blood-Brain Interfaces Efficient in Protecting the Brain From Reactive Molecules? J.-F. Ghersi-Egea, et al.
- The Roles of P-Glycoprotein and MRP1 in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; A.H. Schinkel.
- Are Dopamine, Norepinephrine, and Serotonin precursors of Biologically Reactive Intermediates Involved in the Pathogenesis of Neurodegenerative Brain Disorders? G. Dryhurst.
- Serotonergic Neurotoxicity of Methylenedioxyamphetamine and Methylenedioxymetamphetamine; T.J. Monks, et al.
Session VI.
- Caspase Cascades in Chemically-Induced Apoptosis; S.B. Bratton, G.M. Cohen.
- Spermatogenesis by Sisyphus: Proliferating Stem Germ Cells Fail to Repopulate the Testis After `Irreversible' Injury; K. Boekelheide, H.A. Schoenfeld.
- The Interaction of 1,4-Benzoquinone, A Bioreactive Intermediate of Benzene, With Three Proteins Essential for Differentiation? Maturation of the Mouse Myeloid Stem Cell; G.F. Kalf, et al.
- Hematopoietic Stem and Progenitor Cells as Targets for Biological Reactive Intermediates; R.D. Irons, et al.
Session VII.
- Tobacco Toxicology Revisited; H. Witschi.
- Functional Genomics of Oxidant-Induced Lung Injury; G.D. Leikauf, et al.
- Mitochondrial-derived Oxidants and Quartz Activation of Chemokine Gene Expression; K.E. Driscoll, et al.
- Quinoids as Reactive Intermediates in Estrogen Carcinogenesis; J.L. Bolton, M. Chang.
Session VIII.
- Inhibition of Carcinogenesis and Toxicity by Dietary Constituents; C.S. Yang.
- Modelling the Responses to Biological Reactive Intermediates: Establishing the Borderlines of Risk; P.J. van Bladeren, et al.
- Interindividual Differences in Response to Chemoprotection Against Aflatoxin-Induced Hepatocarcinogenesis: Implifications for Human Biotransformation Enzyme Polymorphisms; D.L. Eaton, et al.
- Sequestration of Biological Reactive Intermediates by Trapping as Covalent Enzyme-Intermediate Complex; F. Oesch, et al.
- Chemoprotection and Interindividual Differences in Response to Biological Reactive Intermediates; R. Thier.
- Oxidative Stress, Glucose-6-Phosphate Dehydrogenase and the Red Cell; D.J. Jollow, D.C. McMillan.
- Short Communications.
Session IX.
- Reactive Intermediates in Biological Systems: What Have we Learned and Where are we Going? F.P. Guengerich, et al.
- Short Communications.
Workshop on Utilization
of Covalent Binding Data in Risk Assessment.
Session I: Covalent
binding to Proteins. The Role of Toxicological Science in Risk Assessment and Risk Management; B.D. Goldstein.
- Oxidative Stress, Glucose-6-Phosphate Dehydrogenase and the Red Cell; D.J. Jollow, D.C. McMillan.
- Covalent Binding of Chemical Residues: Health Impact; A.Y.H. Lu.
- Identification of Hepatic Protein Targets of the Reactive Metabolites of the Non-Heptatotoxic Regioisomer of Acetaminophen, 3'-Hydroxyacetanilide, in the Mouse in vivo
- Using Two-Dimensional Gel Electrophoresis and Mass Spectrometry; Y. Qiu, et al.
Session II:
Covalent Binding to DNA. Exocyclic DNA Adducts as Secondary Markers for Oxidative Stress: Applications in Human Cancer Etiology and Risk Assessment; H. Bartsch, J. Nair.
- Dose Dependent Induction of DNA Adducts, Gene Mutations, and Cell Proliferation by the Antiandrogenic Drug Cyproterone Acetate in Rat Liver; T. Wolff, et al.
- Dose-Dependent Differences in the Profile of Mutations Induced by Carcinogenic (R,S,S,R)
- Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons; A.H. Conney, et al.
- Nucleic Acid Microarray Technology for Toxicology: Promise and Practicalities; D.E. Heck, et al.
- Use of Covalent Binding in Risk Assessment; H. Greim.
- Modulation Influence of p-Chloromercuribenzoate on Plasma Membrane Na+-Ca2+ Exchanger of the Secretory Cells of Chironomus
- Larvae Salivary Gland; N.V. Fedirko, et al.
- Pharmacokinetics of Benzene Following an Oral or Intradermal Dose in FVB and Tg.AC Mice; M.J. Hoffmann, et al.
- Preventive Effect of Selenium of T-2 Toxin Membrane Toxicity; S.A. Keshavarz, et al.
- The Potential Role of Topoisomerase II Inhibition in Hydroquinone-Induced Alterations in the Maturation of Mouse Myeloblasts; M.J. Hoffmann, et al.
- Metabolism of the Food Mutagen 2-Amino-3,8-Dimethylimidazo `4,5=f' Quinoxaline in Human Hepatocytes; S. Langouët, et al.
- Comparison of Two Methods: Culture of Vaginal Discharges and Indirect Fluorescent Antibody for Diagnosis of Listeria Monocytogenes in Pregnant Women; F.A. Nakhjavani, et al.
- Synthesis and Evaluation of New Male Contraceptives; H.R.S. Roodsarie, et al.
- Metabolism of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) in A/J Mouse Lung and Effect of Cigarette Smoke Exposure on In Vivo
- Metabolism to Biological Reactive Intermediates; A.R. Tricker, et al.
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Autoren-Porträt
Helmut Greim is Head of the DFG-Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area and also President of the Advisory Committee on Existing Chemicals of Environmental Relevance of the German Chemical Society. Both bodies are intimately involved in European regulatory procedures concerning hazardous chemicals.
Bibliographische Angaben
- 2012, 2001, XV, 728 Seiten, Maße: 17,8 x 25,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: Patrick M. Dansette, Robert R. Snyder, Terrence J. Monks, David J. Jollow, I. Glenn Sipes, Helmut Greim, G. Gordon Gibson, Marcel Delaforge
- Verlag: Springer, Berlin
- ISBN-10: 1461351855
- ISBN-13: 9781461351856
Sprache:
Englisch
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