Biomarkers in Inflammatory Bowel Diseases

Part I: Introduction.-

1. Inflammatory bowel disease - more than meets the eye

2. Clinical risk factors - lessons from epidemiology

3. Clinical trial design for biomarker discovery

4. Database/ big data meets real world 5. Patient reported outcomes

Part II: Biomarkers

6. Prognostic vs Predictive

7. Biomarkers for remote monitoring

8. Disease modification

Part IIV: Crohn's disease

9. Luminal Crohn's disease

10. Perianal CD

11. Fibrosis/ strictures in CD

12. Post-op Crohn's disease

Part IV: Ulcerative colitis

13. UC surveillance

14. Acute severe UC

15. Chronic active UC

16. Pouchitis

17. Refractory proctitis

18. Feacal microbiota transplantation

19. Primary sclerosing cholangitis

20. Extraintestinal manifestations of IBD

Part V: Specialised scenarios

21. Pregnancy

22. Nutrition

23. TDM

24. Biomarkers to quantify immune response

25. Drug toxicity

Part VI:Scientific

26. Exposome and diet

27. Microbiota

28. Metabonomics

29. Immunology

30. Genomics

31. Systems Biology in Biomarker research

Part VII: Ideal tools for investigation in the future

The editors are currently reviewers of major international journals. They are experts in inflammatory bowel disease (IBD) each with an interest in developing biomarkers for research development and improving patient care. The editors have also developed strong reputations within the international IBD community and have connections with each of the nominated chapter contributors.

Nik Sheng Ding is a committee member for the European Crohn's and Colitis Organisation (ECCO) and a clinical lecturer at Imperial College, London. He has supervised students and is a member of the Computational Medicine division of the department of medicine. He is completing a PhD entitled "Clinical and metabolic predictors of response to anti-TNF therapy in Crohn's disease". He has authored and co-authored manuscripts, book chapters and has a major grant from ECCO to conduct his research. He is currently the principal investigator of an international study into access to IBD investigations (biomarkers) by health professionals, particularly investigating rates of usage according to health expenditure and quality of care for patients (Access to IBD investigations - ACCID). Nik has an interest in translational research with investigating the function of the microbiome through metabonomics and it's relation to outcomes in IBD.

Peter De Cruz MBBS, Ph.D, FRACP Peter De Cruz is Director of the IBD service at the Austin Hospital, Senior lecturer at the University of Melbourne and Life Fellow of Clare Hall at the University of Cambridge.  Peter's doctoral research at The University of Melbourne identified the optimal strategy for preventing Crohn's disease recurrence after resectional surgery. The findings of the research have been published in the Lancet and Gastroenterology and have changed practice internationally. His postdoctoral fellowship in complex IBD and clinical nutrition was undertaken between Addenbrooke's Hospital, Cambridge and St Mark's Hospital, London.