Genomic Elements in Health, Disease and Evolution
Junk DNA
(Sprache: Englisch)
Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the "junk" DNA since it does not code for any "useful" protein product. Over the last years this notion changed...
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Klappentext zu „Genomic Elements in Health, Disease and Evolution “
Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the "junk" DNA since it does not code for any "useful" protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.
Inhaltsverzeichnis zu „Genomic Elements in Health, Disease and Evolution “
Chapter 1 MiRNAs' Function and Role in Evolution: Under the View of Genomic Enhancement Phenomena Konstantinos Voskarides and Kyriacos Felekkis Chapter 2 MicroRNAs in Disease Gregory Papagregoriou Chapter 3 piRNAs- Transposon Silencing and Germ Line Development Catherine Demoliou Chapter 4 Long Non-Coding RNA Monika Gullerova Chapter 5 Unveiling Transposable Elements Function to Enrich Knowledge for Human Physiology and Disease Pathogenesis Ioannis S. Vizirianakis, Elsa P. Amanatiadou, and Sotirios S. Tezias Chapter 6 Copy Number Variation in Human Health, Disease and Evolution Carolina Sismani, Costas Koufaris, and Konstantinos Voskarides Chapter 7 Mini- And Micro-Satellite Markers in Health, Disease and Evolution Vasiliki A. Galani, Sofia Markoula, Leandros Lazaros, Paris Ladias, Ioannis Georgiou Chapter 8 Intron Biology, Focusing on Group II Introns, the Ancestors of Spliceosomal Introns María Dolores Molina-Sánchez, Rafael Nisa-Martínez, Fernando M. García-Rodriguez, Francisco Martínez-Abarca, Nicolás Toro Chapter 9 Centromeres in Health, Disease and Evolution Thian Thian Beh and Paul Kalitsis Chapter 10 Structure and Functions of Telomeres in Organismal Homeostasis and Disease Penelope Kroustallaki and Sarantis Gagos Chapter 11 Proximal Regulatory Elements with Emphasis on CpG Rich Regions Pavlos Fanis Chapter 12 Genomic Analysis through High-Throughput Sequencing Michalis Hadjithomas
Bibliographische Angaben
- 2015, 1st ed. 2015, XI, 315 Seiten, 34 farbige Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Kyriacos Felekkis, Konstantinos Voskarides
- Verlag: Springer, Berlin
- ISBN-10: 1493930699
- ISBN-13: 9781493930692
- Erscheinungsdatum: 02.10.2015
Sprache:
Englisch
Pressezitat
"This is the first time I have seen a volume on genomics from the island of Cyprus. ... The chapters are well written, are of high quality, and the references cited reflect an intimate knowledge of current literature. ... This is a useful source for an introduction to the noncoding regions of the human genome." (Krishna Dronamraju, The Quarterly Review of Biology, Vol. 92 (2), June, 2017)Kommentar zu "Genomic Elements in Health, Disease and Evolution"
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