Innate and Adaptive Immunity in the Tumor Microenvironment
(Sprache: Englisch)
Traditionally, the interplay between cancer cells and host immunity has been studied systemically. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of...
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Klappentext zu „Innate and Adaptive Immunity in the Tumor Microenvironment “
Traditionally, the interplay between cancer cells and host immunity has been studied systemically. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. This volume compiles reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease.
Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues.
Inhaltsverzeichnis zu „Innate and Adaptive Immunity in the Tumor Microenvironment “
Foreword - Tumor Microenvironment under the Magnifying Glass: A New Challenge to Cancer ImmunologistsEitan Yefenof Chapter 1: Immune Effector Cells in the Tumor Microenvironment: Their Role in Regulation of Tumor ProgressionTheresa L. Whiteside Chapter 2: Histocompatibility Antigens, Tumor Microenvironment and Escape Mechanisms Utilized by Tumor CellsSoldano Ferrone and Theresa L. Whiteside Chapter 3: Local Tumor Growth and Spontaneous Systemic T cell Responses in Cancer Patients: a Parodox and PuzzlePhilipp Beckhove and Volker Shirrmacher Chapter 4: Insights into mechanisms of immune resistance in the tumor microenvironment through molecular profilingThomas F. Gajewski Chapter 5: Tumor Antigens as Modulators of the Tumor MicroenvironmentKatja Engelmann and Olivera J. Finn Chapter 6: Tumor Cell Resistance to Apoptosis by Infiltrating Cytotoxic LymphocytesBenjamin Bonavida Chapter 7: The Tumor Microenvironment as a Model for Tissue-Specific RejectionSilvia Selleri, Sara Deola, Cristiano Rumio and Francesco M. Marincola Chapter 8: Functional Cytotoxicity of T Cells at the Tumor EnvironmentMichal Lotem, Arthur Machlenkin, Shoshana Frankenburg and Tamar Peretz Chapter 9: Natural Killer Cells at the Tumors MicroenvironmentRoi Gazit and Ofer Mandelboim Chapter 10: Contribution of the Microenvironment to the Pathogenesis of EBV-positive Hodgkin and NK/T-cell LymphomasEva Klein, M. Takahara and LL Kis
Bibliographische Angaben
- 2007, 2008, 212 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben:Yefenof, Eitan
- Herausgegeben: Eitan Yefenof
- Verlag: Springer Netherlands
- ISBN-10: 1402067496
- ISBN-13: 9781402067495
- Erscheinungsdatum: 04.12.2007
Sprache:
Englisch
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