Mathematical, Computational and Experimental T Cell Immunology

Cytokine receptor signaling and CD4/CD8 lineage choice during T cell development in the thymus.- An agent-based model of T helper cell fate decisions in the thymus.- Modelling naive T cell homeostasis.- Mechanistic models of CD4 T cell homeostasis and reconstitution in health and disease.- Section 1MODELING THE DYNAMICS OF CD4+ T CELLS IN HIV- 1 INFECTION.- Modelling the response to Interleukin-7 therapy in HIV-infected patients.- Modeling immunopathology during persistent viral infections.- Delay in differentiation may suggest division of labour in models for CD8+ T cell differentiation.- Inferring differentiation order in adaptive immune responses from population level data.- Experimental and mathematical approaches to quantify recirculation kinetics of lymphocytes.- The public face and private lives of T cell receptor repertoires.- Population dynamics of immune repertoires.- Mathematical Modelling of T cell activation.- Agent-based model of heterogeneous T cell activation in vitro.- CTLA-4 mediated ligand trans-endocytosis: a stochastic model.- Automated gating and dimension reduction of high-dimensional cytometry data.- Index

Grant Lythe and Carmen Molina-París are Professors of Applied Mathematics at the University of Leeds. They have coordinated the FP7 Initial Training Network on Quantitative T cell Immunology (2013-2017) and they currently coordinate the H2020 Innovative Training Network on Quantitative T cell Immunology and Immunotherapy (2018-2022).