Membrane Biogenesis

1 Signals for Protein Targeting into and across Membranes.- 1. Introduction.- 2. Signals in the Secretory Pathway.- 3. Signals for Mitochondrial Protein Import.- 4. Signals for Chloroplast Protein Import.- 5. Signals for Nuclear Protein Import.- 6. Signals for Peroxisomal Import.- 7. Signals for Membrane Protein Assembly.- 8. Conclusions.- 9. References.- 2 Insertion of Proteins into Membranes: A Survey.- 1. Introduction.- 2. Structure of Membrane Proteins.- 3. Folding of Integral Membrane Proteins.- 4. Transmembrane Topology.- 5. Mechanisms of Insertion of Membrane Proteins.- 6. Membrane Insertion of Toxins.- 7. Conclusions.- 8. References.- 3 The Major Glycosylation Pathways of Mammalian Membranes: A Summary.- 1. Introduction.- 2. The ER-Golgi-Plasmalemma Pathway.- 3. Nuclear and Cytoplasmic Glycosylation.- 4. References.- 4 Compartments of the Early Secretory Pathway.- 1. Introduction.- 2. Compartments.- 3. Endoplasmic Reticulum.- 4. Intermediate Compartments.- 5. Conclusions.- 6. References.- 5 Assembly of Mitochondrial Membranes.- 1. Introduction.- 2. Synthesis and Targeting of Nuclear-Encoded Mitochondrial Proteins: The General Targeting Pathway.- 3. Assembly of Proteins into the Mitochondrial Outer Membrane.- 4. Assembly of Proteins in the Mitochondrial Inner Membrane.- 5. Lipid Synthesis and Localization.- 6. Conclusions.- 7. References.- 6 The Assembly of Chloroplast Membranes.- 1. Introduction.- 2. Chloroplast Structure and Biogenesis.- 3. Transport of Proteins into the Stroma.- 4. The Import and Sorting of Thylakoid Proteins.- 5. Transport of Proteins into the Chloroplast Envelope.- 6. Summary.- 7. References.- 7 Biogenesis of the Lysosomal Membrane.- 1. Introduction.- 2. Mannose Phosphate Receptors.- 3. Isolation of Lysosomal Membrane Glycoproteins.- 4. Roles of Cytoplasmic Tails in Intracellular Traffic.- 5. Cell Surface Expression of Lysosome Membrane Glycoproteins.- 6. Roles of Carbohydrates in Lamp Molecules.- 7. References.- 8 Assembly of the