Metabolism and Functions of Bioactive Ether Lipids in the Brain
(Sprache: Englisch)
Information on bioactive ether lipids and their involvement in neurological disorders is currently scattered throughout the literature. This book provides readers with a comprehensive description of metabolism of bioactive ether lipids in the brain,...
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Klappentext zu „Metabolism and Functions of Bioactive Ether Lipids in the Brain “
Information on bioactive ether lipids and their involvement in neurological disorders is currently scattered throughout the literature. This book provides readers with a comprehensive description of metabolism of bioactive ether lipids in the brain, activities of enzymes involved in their metabolism, and their involvement in neurological disorders. It is the first book to describe the involvement of these lipids with abnormal signal transduction processes in neurological disorders.
Inhaltsverzeichnis zu „Metabolism and Functions of Bioactive Ether Lipids in the Brain “
Occurrence and importance of ether lipids in brain.- Introduction.- Classification of ether lipids found in brain.- Physicochemical properties of ether lipids.- Fecapentaenes, the novel plasmalogens.- Other ether lipid found in mammalian tissues.- Lipid metabolism in ether lipid-deficient mice.- Conclusion.- Biosynthesis of plasmalogens in brain.- General considerations and distribution of plasmalogens in brain.- Biosynthesis of plasmalogens.- Dihydroxyacetone phosphate acyltransferase.- Alkyl-dihydroxyacetone phosphate synthase.- Acyl/alkyl dihydroxyacetone phosphate reductase 2.2.4. Alkyl-GP acyltransferase.- Alkylacyl-GP phosphohydrolase.- CDP-ethanomamine: diacylglycerol ethanolaminephosphotransferase.- Plasmalogen synthesizing enzymes during brain development.- Topology and distribution of plasmalogen and plasmalogen synthesizing enzymes.- Plasmalogens in lipid rafts.- Plasmalogens in the nucleus.- Factors affecting plasmalogen biosynthesis in brain.- Conclusion.- Catabolism of plasmalogens in brain.- Introduction.- Plasmalogen-selective phospholipase A2.- Receptor-mediated degradation of plasmalogens.- Regulation of PlsEtn-PLA2.- Turnover of Plasmalogen in brain.- Remodeling of plasmalogens (Reacylation/deacylation reactions).- Degradation of plasmalogens by phospholipase C.- Non-enzymic oxidation of plasmalogens in brain.- Plasmalogen-derived lipid mediators and their importance in brain.- Lysoplasmalogens in brain.- Conclusion.- Assay and purification of plasmalogen-selective phospholipase A2 and lysoplasmalogenase activities.- Introduction.- Determination of PlsEtn and PlsCho-PLA2 by radiochemical procedures.- Preparation of radiolabled [3H] plasmenylcholine (choline plasmalogen).- Labeling of lysoplasmenylcholine at the sn-2 position.- Determination of PlsCho-PLA2 activity.- Determination of PlsEtn-PLA2 by fluorometric assay.- Purification of ethanolamine plasmalogen.- Labeling of ethanolamine
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plasmalogen with pyrenesulfonyl chloride.- Determination of PlsEtn-PLA2 activity with pyrene-labeled plasmalogen.- Continuous spectrophotometric determination of PlsEtn-PLA2.- Determination of lysoplasmalogenase.- Continuous spectrophotometric procedure for lysoplasmalogenase.- Continuous spectrofluorometric procedure for lysoplasmalogenase.- Activities of plasmalogen-selective PLA2 in brains of various animal species and cultured cells of neuronal and glial origin.- Determination of lysoplasmalogenase activity in rat liver and brain microsomes.- Purification of plasmalogen-selective PLA2 from brain.- Purification of lysoplasmalogenase from liver.- Conclusion.- Roles of plasmalogens in brain.- Introduction.- Roles of plasmalogens in brain.- Plasmalogens as neural membrane components.- Plasmalogens as a storage depot for second messengers.- Plasmalogens in regulation of enzymic activities.- Plasmalogens in membrane fusion.- Plasmalogens in ion transport.- Plasmalogens in high density lipoprotein.- Plasmalogen, cholesterol oxidation, efflux and atherosclerosis.- Plasmalogens and their antioxidant activity.- Plasmalogen and generation of long-chain aldehydes.- Plasmalogen in differentiation.- Plasmalogens in ocular development.- Plasmalogens as precursors for PAF.- Conclusion.- Involvement of plasmalogens in neurological disorders.- Introduction.- Plasmalogens in neurological disorders.- Plasmalogens in ischemic injury.- Plasmalogens in Alzheimer disease.- Plasmalogens in spinal cord injury.- Plasmalogens in peroxisomal disorders.- Plasmalogens in Sjogren-Larsson syndrome.- Plasmalogens in malnutrition.- Plasmalogens in fetal alcohol syndrome.-
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Bibliographische Angaben
- Autoren: Akhlaq A Farooqui , Tahira Farooqui , Lloyd A. Horrocks
- 2008, 260 Seiten, Maße: 16,6 x 24,4 cm, Gebunden, Englisch
- Verlag: Springer, New York
- ISBN-10: 0387774009
- ISBN-13: 9780387774008
Sprache:
Englisch
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