MicroRNAs as Tools in Biopharmaceutical Production
(Sprache: Englisch)
Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on...
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Klappentext zu „MicroRNAs as Tools in Biopharmaceutical Production “
Focused manuscript on the potential use/role of miRNAs in bioprocessing, specifically the production of complex proteins in mammalian cells. With that in mind I propose a draft list of topics/chapters along the following lines: Intro on CHO/bioprocessing/engineering challenges to set scene, Genomic organization, biogenesis and mode of action, Identifying miRNA targets: Computational prediction, transcriptomics, proteomices, UTR analysis, etc., miRNA expression in Chinese Hamster Ovary cells, miRNAs as engineering targets: pathway manipulation to impact bioprocess phenotypes, miRNAs as biomarkers, Detection methods: Northern, PCR, hybridization arrays, Next Gen Seq, Manipulation of expression in cultured cells: Transient/stable disregulation, Knockout.
Inhaltsverzeichnis zu „MicroRNAs as Tools in Biopharmaceutical Production “
Preface1 A general introduction to microRNAs, their investigation and exploitation in CHO cell lines2 Biogenesis of Mammalian miRNA3 Target prediction algorithms and bioinformatics resources for miRNA studies4 The CHO miRNA transcriptome5 MicroRNAs as engineering targets - pathway manipulation to impact bioprocess phenotypes6 MicroRNAs for Enhancement of CHO Cell Proliferation and Stability Insights from Neuroblastoma Studies7 MicroRNA Detection Methods for Mammalian Cell Lines and Their Applications in Therapeutic Protein Production8 Manipulating Levels of Specific microRNAs in Mammalian CellsIndex.
Bibliographische Angaben
- 2012, 136 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Niall Barron
- Verlag: Springer Netherlands
- ISBN-10: 9400751273
- ISBN-13: 9789400751279
- Erscheinungsdatum: 16.11.2012
Sprache:
Englisch
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