New Advances in Histamine Research

concentrations in hypophysectomized animals.- 9. Histamine depletion in rat brain and its influence on corticosterone release.- 10. Influence of lesions or stimulation to the posterior hypothalamus.- 11. Interaction between the posterior hypothalamus and the adrenal gland.- 12. Effects of some neurotransmitters on steroidogenesis in dog adrenocortical cells.- 13. Conclusion.- References.- 4 Role of Ca2+ and cAMP in histamine release from mast cells.- 1. Intracellular Ca2+ release induced by histamine releasers and its inhibition by some antiallergic drugs.- 2. Inhibition of intracellular Ca mobilization, Ca uptake and histamine release induced by some antiallergic drugs.- 3. Sequential analysis of histamine release and intracellular Ca2+ release from murine mast cells.- 4. Ca uptake and Ca releasing properties of the endoplasmic reticulum in rat peritoneal mast cells.- 5. Role of endoplasmic reticulum, an intracellular Ca2+ store, in histamine release from mast cell.- 6. Histamine release from ?-escin-permeabilized rat peritoneal mast cells and its inhibition by intracellular Ca2+ blockers, calmodulin inhibitors and cAMP.- 7. Role of ATP and activation of protein kinase C in Ca2+-dependent histamine release from permeabilized rat mast cells.- 8. Ca2+-induced translocation of protein kinase C during Ca2+-dependent histamine release from ?-escin-permeabilized mast cells.- 9. Phosphorylation of smg p21B in rat peritoneal mast cells in association with histamine release inhibition by dibutyryl-cAMP.- References.- 5 Role of cytoskeleton in the histamine release from mast cells.- 1. Role of microfilaments in the exocytosis of rat peritoneal mast cells.- 2. Microfilament-associated degranulation.- 3. Role of microtubules on Ca2+ release from the endoplasmic reticulum and associated histamine release from rat peritoneal mast cells.- 4. Identification of vimentin in rat peritoneal mast cells and its phosphorylation in association with histamine release.- References.- 6 Histamine release induced by basic peptides and proteins.- 1. Substance P-induced histamine release from rat peritoneal mast cells and its inhibition by antiallergic agents and calmodulin inhibitors.- 2. Histamine release induced by histone and related morphological changes in mast cells.- 3. Guinea pig eosinophil major basic protein as a potent histamine releaser.- References.- 7 Inhibitory effect of interleukin-2 on the histamine release from rat peritoneal mast cells in association with the production of lipocortin-I.- 1. Introduction.- 2. Inhibitory effects of interleukin-2 on histamine release from rat peritoneal mast cells induced by compound 48/80 and concanavalin A.- 3. Effect of IL-2 on 45Ca uptake and IP3 production in rat peritoneal mast cells.- 4. Effect of IL-2 on cAMP-protein kinase A system in rat mast cells.- 5. [3H] -Leucine uptake into rat mast cells elicited by IL-2.- 6. Determination of the protein synthesis elicited by IL-2.- 7. Western blotting analysis of lipocortin-I induced by IL-2.- 8. Participation of tyrosine kinase in histamine release inhibition due to IL-2.- 9. Discussion.- References.- 8 Histamine-induced leukocytosis.- 1. Introduction.- 2. Histamine-induced leukocytosis in experimental animals.- 3. Effect on neutrophil precursors.- 4. Histamine and cell proliferation.- 5. Histamine-induced differentiation of HL-60 cells: Analysis of the mechanism of action of histamine.- 6. Effect of histamine on IL-1 production in bone marrow stromal cells.- 7. Histamine-induced extemalization of G-CSF receptor.- References.- 9 Pharmacology of newly developed H1 antagonists: antiallergic profile of H1 antagonists.- 1. Introduction.- 2. Determination of Hi antagonistic activity (isolated guinea pig ileum).- 3. Effect on histamine release and SRS-A release.- 4. Effect on 45Ca uptake and intracellular Ca mobilization.- 5. The role of cyclic nucleotide for inhibition of histamine release.- 6. Effect on bronchoconstriction in guinea pigs.- 7. Effect on cutaneous reaction in rats.- 8. Effect on experimental allergic rhinitis.- 9. Effect on experimental allergic conjunctivitis.- 10. Effect on LTs- or PAF-induced contractions of isolated guinea pig trachea.- 11. Effect on rabbit platelet aggregation induced by PAF.- 12. Effect on the central nervous system.- 13. conclusion.- References.