Phenotypes and Genotypes
Search for Influential Genes
(Sprache: Englisch)
This book explores association mapping in experimental populations and genome-wide association studies (GWAS), emphasizing methods based on modifications of Bayesian information criterion, for handling testing problems in large-scale scans for trait loci.
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This book explores association mapping in experimental populations and genome-wide association studies (GWAS), emphasizing methods based on modifications of Bayesian information criterion, for handling testing problems in large-scale scans for trait loci.
Klappentext zu „Phenotypes and Genotypes “
Thistimely text presents a comprehensive guide to genetic association, a new andrapidly expanding field that aims to elucidate how our genetic code (genotypes)influences the traits we possess (phenotypes). The book provides a detailedreview of methods of gene mapping used in association with experimentalcrosses, as well as genome-wide association studies. Emphasis is placed onmodel selection procedures for analyzing data from large-scale genome scansbased on specifically designed modifications of the Bayesian informationcriterion. Features: presents a thorough introduction to the theoreticalbackground to studies of genetic association (both genetic and statistical); reviewsthe latest advances in the field; illustrates the properties of methods formapping quantitative trait loci using computer simulations and the analysis ofreal data; discusses open challenges; includes an extensive statisticalappendix as a reference for those who are not totally familiar with thefundamentals of statistics.Inhaltsverzeichnis zu „Phenotypes and Genotypes “
Introduction.- A Primer in Genetics.- Statistical Methods in High Dimensions.- Statistical Methods of QTL Mapping for Experimental Populations.- Statistical Analysis of GWAS.- Appendix A: Basic Statistical Distributions.- Appendix B: Basic Methods of Estimation.- Appendix C: Principles of Statistical Testing.- Appendix D: Elements of Bayesian Statistics.- Appendix E: Other Statistical Methods.Autoren-Porträt von Florian Frommlet, Malgorzata Bogdan, David Ramsey
Dr. Florian Frommlet is an Assistant Professor at the Department of Statistics and Decision Support Systems of the University of Vienna, Austria.Dr. Ma?gorzata Bogdan is an Associate Professor at the Institute of Mathematics and Computer Science of Wroc?aw University of Technology, Poland.
Bibliographische Angaben
- Autoren: Florian Frommlet , Malgorzata Bogdan , David Ramsey
- 2016, 1st ed. 2016, XII, 222 Seiten, 20 farbige Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 144715309X
- ISBN-13: 9781447153092
- Erscheinungsdatum: 24.02.2016
Sprache:
Englisch
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