STRUCTURE-BASED DRUG DISCOVERY
(Sprache: Englisch)
This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental...
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Klappentext zu „STRUCTURE-BASED DRUG DISCOVERY “
This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.
Inhaltsverzeichnis zu „STRUCTURE-BASED DRUG DISCOVERY “
- Five Years of Increasing Structural Biology Throughput- A Retrospective Analysis
- Protein Production For Structural Genomics
- Strategies for the Next Phase
- Introduction to Fragment Screening
- Fragment-based NMR Screening in Lead Discovery
- Fragment-based Screening by X-Ray Crystallography
- Scaffold-based Drug Discovery
- Biophysical Methods
- Illustration of Current Challenges in Molecular Docking
- Scoring Functions
Bibliographische Angaben
- XII, 252 Seiten, Maße: 16,3 x 24,4 cm, Gebunden, Englisch
- Herausgegeben: Harren Jhoti, Andrew R. Leach
- Verlag: Springer Netherland
- ISBN-10: 1402044062
- ISBN-13: 9781402044069
- Erscheinungsdatum: 09.01.2007
Sprache:
Englisch
Rezension zu „STRUCTURE-BASED DRUG DISCOVERY “
From the reviews:"Structure-based drug design (SBDD) is now an integral component of the drug discovery process. ... The book's core subject matter of fragment-based screening is an exciting and important development in drug discovery. These chapters are generally the strongest in the book and make it a good reference volume ... ." (Robert Powers, Journal of the American Chemical Society, Vol. 129 (32), 2007)
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