Textbook of Von Willebrand Disease

List of Contributors, vii Foreword, xi Preface, xiii 1 Historical perspective on von Willebrand disease, 1 Erik E. Berntorp and Margareta Blombäck 2 Biosynthesis and organization of von Willebrand factor, 7 Sandra L. Haberichter 3 Von Willebrand factor structure and function, 23 Robert R. Montgomery, Veronica H. Flood, and Sandra L. Haberichter 4 Regulation of von Willebrand factor expression, 39 Elham Ghorbanpour and David Lillicrap 5 Modulation of VWF by ADAMTS13, 49 Yaoxian Xu, Anastasis Petri, and James T.B. Crawley 6 Assessment of VWF clearance, 63 Orla Rawley, Laura L. Swystun, and Jamie M. O'Sullivan 7 Classification of VWD, 73 Jessica Garcia, Sandra L. Haberichter, and Veronica H. Flood 8 The epidemiology of von Willebrand disease, 81 Giancarlo Castaman and Francesco Rodeghiero 9 Clinical aspects of von Willebrand disease: bleeding history, 87 Paula D. James and Alberto Tosetto 10 Laboratory diagnosis of von Willebrand disease: the phenotype, 95 Emmanuel J. Favaloro and Ulrich Budde 11 Molecular diagnosis of von Willebrand disease: the genotype, 109 Pamela Christopherson, Robert R. Montgomery, and Veronica H. Flood 12 Clinical, laboratory, and molecular markers of type 1 von Willebrand disease and low von Willebrand factor, 115 David Lillicrap 13 Clinical and molecular markers of type 1C VWD, 123 Heather Clift, Veronica H. Flood, and Sandra L. Haberichter 14 Clinical and molecular markers of VWD2A, 129 Reinhard Schneppenheim and Giancarlo Castaman 15 Clinical and molecular markers of VWD2B, 137 Giancarlo Castaman and Augusto B. Federici 16 Clinical and molecular markers of type 2M VWD, 143 Maissaa Janbain, Sandra L. Haberichter, and Veronica H. Flood 17 Clinical and molecular markers of VWD2N, 149 Jenny Goudemand and Mélanie Daniel 18 Clinical, laboratory, and molecular markers of type 3 von Willebrand disease, 159 Luciano Baronciani and Augusto B. Federici 19 Pediatric aspects of von Willebrand disease, 177 Robert F. Sidonio Jr and Jorge Di Paola 20 Women

Professor Augusto B. Federici, Hematology and Transfusion Medicine, L. Sacco University Hospital and University of Milan, Milan, Italy.

Professor Erik E. Berntorp, Department of Translational Medicine, Malmö Centre for Thrombosis and Haemostasis, Lund University, Skåne University Hospital, Malmö, Sweden.

Professor David Lillicrap, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada.

Professor Robert R. Montgomery, Pediatrics (Hematology) and Vice Chair, Versiti Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI, USA.