The Adenosine Receptors

Purinergic signalling: an historical overview.- Regulation of extracellular adenosine.- Adenosine receptors: structure, distribution and signal transduction.- Binding thermodynamic characteristics of adenosine receptor ligands.- A1 adenosine receptor agonists, antagonists and allosteric modulators.- A2A adenosine receptor: structure, function and medicinal chemistry.- Medicinal chemistry of A2B adenosine receptors.- A3 adenosine receptor: medicinal chemistry of orthosteric and allosteric ligands and structural probing.- Adenosine Receptors and Neuroinflammation.- Adenosine receptors as paradigm to identify dimer/oligomers of G-protein-coupled receptors and as targets in Parkinson's disease.- Adenosine receptors in Alzheimer's disease.- What is the role of adenosine receptors in Huntington Disease?.- Adenosine receptors: a novel target for homeostatic control of cognition.- Roleof Adenosine Receptors in Epileptic Seizures.- Adenosine signaling in brain Ischemia.- Adenosine and traumatic brain injury.- Adenosine and its receptors in pain.- Adenosine signalling in the injured heart.- Adenosine receptors in the lungs.- Adenosine and renal function in health and disease.- Adenosine regulation of the immune system.- Adenosine receptors regulate skeletal biology.- Adenosine receptors  in gestational diabetes mellitus and obesity.- Adenosine receptors: current research and their involvement in cancer.- Adenosine receptors as a biological pathway for pulsed electromagnetic fields.

Pier Andrea Borea received his degree in Chemistry Summa cum Laude from the University of Ferrara in 1967. He moved as Visiting Professor to Preclinical Research Department, Sandoz, Basel (CH) and to Medical Research Council Molecular Neurobiology Unit, Cambridge (UK). At present he is Honorary Professor of Pharmacology and member of the Board of Directors at the University of Ferrara. He is member of the Italian Society of Pharmacology and Purine Club. He has published 400 publications in international journals and contributed about 20 chapters to International Books. He has participated in more than 200 congresses, presenting main, oral and poster communications. He is also named as inventor in about 20 Patents. He has been invited to give about 50 Plenary Lectures at International Symposia and at several Universities. His main field of interest is represented by the study, at the molecular level, of drug-receptor interactions and in particular of the P1 adenosine receptor system.

Katia Varani received her degree in Biology in 1988 and her Ph.D. in Cellular and Molecular Pharmacology in 1995 from the University of Ferrara. She is currently Associate Professor of Pharmacology at the Medical Sciences Department of the University of Ferrara. Her research activity mainly involve pharmacological, biochemical and molecular characterization of adenosine receptors in human neurodegenerative diseases, chronic and neuropathic pain, inflammatory diseases and cancer.  She has published 250 publications on peer-reviewed international scientific journals, 15 book chapters and several communications in international and national congresses. She is member of the Italian Society of Pharmacology and Purine Club.

Stefania Gessi received her degree in Biology Summa cum Laude from University of Ferrara in 1994 and her Ph.D. in Cellular and Molecular Pharmacology in 2000 under the guidance of Professor Pier Andrea Borea. She moved at Centro