Theranostics, Gallium-68, and Other Radionuclides

From the contents: Ge-68/Ga-68 generators.- Automation strategies in Ga-68 radiopharmaceutical preparations.- Post-processing via cation exchange cartridges.- Gallium-68 generator integrated system: elution - purification - concentration integration.- Purification and labelling strategies for 68 Ga from 68 Ge/ 68 Ga generator eluate.- 67 Ga and 68 Ga purification studies.- The diversity of [ 68 Ga]Ga-based imaging agents.- Nanoparticles and phage display selected peptides for imaging and therapy of cancer.- "Click" cyclized gallium-68 labeled peptides for molecular imaging and therapy: Synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system.- Early experience with 68 Ga-DOTATATE preparation .- 68 Ga-radiopharmaceuticals for PET imaging of infection and inflammation.- 68 Ga-labeled bombesin analogs for receptor mediated imaging.- A novel 68 Ga-labelled pteroic acid-based PET tracer for tumour imaging via the folate receptor.- Measurement of protein synthesis: In vitro comparison of 68 Ga-DOTA-puromycin, [ 3 H]tyrosine and 2-fluoro-[ 3 H]tyrosine.- Hypoxia imaging agents labeled with positron emitters.- Lu-177/Y-90 intermediate affinity monoclonal antibodies targeting EGFR and HER2/c-neu: preparation and preclinical evaluation.- Divergent role of 68 Ga labeled somatostatin analogs in the work-up of patients with NETs.- Differential uptake of 68 Ga-DOTATOC and 68 Ga-DOTATATE in PET/CT of gastroenteropancreatic neuroendocrine tumours.

From the reviews:

"The general themes of this book (theranostics and peptide receptor-targeted radiotherapy) derive from evolving successes in the use of generator-produced 68Ga for molecular imaging of disease. ... This book is an excellent resource for investigators interested in gaining a detailed understanding of the state of the art in 68Ga and peptide receptor radionuclide therapy-based theranostics for preclinical and emerging clinical applications." -- Michael K. Schultz, The Journal of Nuclear Medicine, Vol. 54 (4), April, 2013

From the reviews:"The general themes of this book (theranostics and peptide receptor-targeted radiotherapy) derive from evolving successes in the use of generator-produced 68Ga for molecular imaging of disease. ... This book is an excellent resource for investigators interested in gaining a detailed understanding of the state of the art in 68Ga and peptide receptor radionuclide therapy-based theranostics for preclinical and emerging clinical applications." (Michael K. Schultz, The Journal of Nuclear Medicine, Vol. 54 (4), April, 2013)