Thrombosis and Hemostasis in Cancer

Thrombosis and Hemostasis in Cancer. Scope of the Problem and Overview.- Pathophysiology 1. Mechanisms of Thrombosis in Cancer Patients.- Pathophysiology 3. The role of platelets in cancer biology.- The risk of thrombosis in cancer. Clinical  factors & possible role of primary prophylaxis.- Biomarkers of cancer-associated thromboembolism.- Thrombotic Risk from Chemotherapy and Other Cancer Therapies.- Treatment of VTE In Cancer. Historical Perspective and evolving role of the DOACs.- Etiology and Management of Upper Extremity, Central line associated thrombosis.- Management of Thrombocytopenia In Cancer Patients.- Microangiopathy in Cancer. Causes, Consequences, and Management.- Thrombosis in the Philadelphia chromosome-negative Myeloproliferative Neoplasms.- Anticoagulation in the setting of primary and metastatic brain tumors.- Hemorrhage in the cancer patient. APML and other specific high risk situations.

Gerald A Soff MD is the Chief of the Hematology Service and co-Director of the Hematology/Oncology Fellowship program at Memorial Sloan Kettering Cancer Center. He previously was the Chief of the Hematology/Oncology Division at SUNY Downstate Medical Center (2006-2008), and had been on the faculty of the Feinberg School of Medicine - Northwestern University (1991-2005). Dr. Soff's clinical practice is focused on the hematologic complications of cancer and cancer therapy, particularly thrombosis, thrombocytopenia, and other coagulation disorders. His basic science research has included studies of vascular cells, angiogenesis, and angiogenesis inhibition. He is a clinical research leader in the study and validation of the use of direct oral anticoagulants for treatment and prophylaxis of cancer associated thrombosis. Dr. Soff has published over 70 original research papers, as well as numerous invited review articles and book chapters. Since 2014, Dr. Soff has been a member of the National Comprehensive Cancer Network Cancer-Associated Venous Thromboembolic Disease panel. Previously, from 2011 to 2014, he had been on the NCCN Cancer and Chemotherapy-Induced Anemia Panel. He is a member of the American Society of Hematology Committee on Training and served as the Medical Education Subcommittee Chair from 2013-2018. He has mentored and continues to mentor numerous students, residents, fellows, and junior faculty, to facilitate their career development.