Translational Regulation of Gene Expression
(Sprache: Englisch)
Given the accelerated growth of knowledge in the field of gene expression, it seemed timely to discuss current developments in the area of translational reg ulation of gene expression as well as to evaluate emerging technology. Translational regulation...
Voraussichtlich lieferbar in 3 Tag(en)
versandkostenfrei
Bisher 88.00 €*
Buch (Kartoniert) -38%
54.99 €
*Preisbindung aufgehoben
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „Translational Regulation of Gene Expression “
Klappentext zu „Translational Regulation of Gene Expression “
Given the accelerated growth of knowledge in the field of gene expression, it seemed timely to discuss current developments in the area of translational reg ulation of gene expression as well as to evaluate emerging technology. Translational regulation occurs with prokaryotic as well as with eukaryotic messenger RNA (mRNA) in vivo and in vitro. In prokaryotes, through genetic manipulations and mutagenesis, the mechanisms are much better understood, as for example the mechanism of attenuation. In bacteria, different translational efficiencies for the same mRNA may vary by lOOO-fold. Translational regulation was first observed in 1966 with RNA phages of Escherichia coli by Lodish and Zinder. However, translational regulation of proteins from DNA genomes is also well described for bacteria, as for example gene 32 protein of bacteriophage T4 and E. coli ribosomal proteins. In eukaryotes, the utilization of an individual mRNA species with different efficiencies is poorly understood. For example, mRNA for ribosomal proteins is translationally regulated during Drosophila oogenesis, without any clue to the mechanism involved. It was observed that ribosomal protein mRNA during Drosophila oogenesis and embryogenesis is selectively on or off the polysomes during different developmental stages. In contrast, bacterial ribosomal protein is also translationally regulated by autogenous regulation. The mechanism is well understood and involves binding of the gene product to its transcript in competition with rRNA.
Inhaltsverzeichnis zu „Translational Regulation of Gene Expression “
1 Translational Regulation of Ribosomal Proteins in Escherichia coli: Molecular Mechanisms.- 1. Evidence for Autoregulation of Ribosomal Proteins.- 2. Regulation of the ? Operon by S4.- 2.1. Introduction.- 2.2. Thermodynamics of S4-Messenger RNA Complex Formation.- 2.3. Structure of the ? Messenger RNA Leader.- 3. Regulation of the L11 Operon by L1.- 4. Regulation of the rif Operon by L10.- 5. Other Ribosomal-Protein Repressors.- 6. Common Themes in Ribosomal-Protein Autoregulation.- 7. Thermodynamics of Translational Repression.- 7.1. Thermodynamics of Translation.- 7.2. Translation and Repression In Vivo.- 8. Predictions of Different Translational Repression Models.- 8.1. Displacement Model.- 8.2. Entrapment Model.- 8.3. Influences of Protein Binding on Messenger RNA Turnover...- 8.4. Prediction of Gene-Dosage Effects.- 9. Influence of Messenger RNA Secondary Structure on Translation...- 10. Future Directions.- References.- 2 Translational Regulation in Bacteriophages.- 1. Introduction.- 2. RNA Phage.- 2.1. Repression by Replicase.- 2.2. Repression by Coat Protein.- 3. T4 Gene 32.- 3.1. Autogenous Translational Repression.- 3.2. Binding Parameters.- 3.3. Quantitative Model of Repression.- 3.4. Tests of the Model.- 4. f1 Gene V.- 5. P22 Gene 8.- 6. T4 RegA Protein.- 7. Structural Repression and Activation.- 8. Conclusions.- References.- 3 Escherichia coli Threonyl-Transfer RNA Synthetase as a Model System to Study Translational Autoregulation in Prokaryotes.- 1. Introduction.- 2. Structure of the Escherichia coli Genome around the Gene for Threonyl-Transfer RNA Synthetase.- 3. The Expression of the Gene for Threonyl-Transfer RNA Synthetase Is Negatively Autoregulated at the Translational Level.- 3.1. In Vitro Studies.- 3.2. In Vivo Studies.- 4. Genetic Definition of the Translational Operator.- 4.1. Isolation of Operator Constitutive Mutants.- 4.2. Nucleotide Sequence of the Operator Constitutive Mutants.- 4.3. Homologies between the thrS Translational Operator and
... mehr
the Threonine-Specific Transfer RNAs.- References.- 4 Translational Regulation of Ribosomal Protein Gene Expression in Eukaryotes.- 1. Introduction.- 2. Translational Regulation of Yeast Ribosomal Protein Synthesis.- 2.1. Genetics of Yeast Ribosomal Proteins.- 2.2. Is There Life after Transcription?.- 2.3. Evidence for Translational Regulation of Yeast Ribosomal Protein Synthesis.- 2.4. Other Aspects of Ribosomal Protein Messenger RNA Translation.- 2.5. Future Directions.- 3. Translational Regulation of Ribosomal Protein Synthesis during Drosophila Development.- 4. Translational Regulation of Ribosomal Protein Synthesis during Xenopus Development.- 5. Translational Regulation of Ribosomal Protein Synthesis during Mammalian Development.- 6. Translational Regulation of Ribosomal Protein Synthesis in Other Eukaryotic Cells.- 7. Conclusions and Prospects.- References.- 5 Selective Messenger RNA Translation in Marine Invertebrate Oocytes, Eggs, and Zygotes.- 1. Introduction.- 2. Translational Control in Sea Urchin Eggs and Embryos.- 2.1. Role of Changes in the Translational Machinery.- 2.2. Role of Changes in the Availability of Messenger RNA.- 3. Quantitative Changes in Other Organisms.- 3.1. Qualitative Changes in Protein Synthesis.- 3.2. Mechanisms of Selective Translation.- 3.3. Regulation of Message Availability through the Association of the Maternal Messenger RNA with Other Macromolecules.- 3.4. Changes in Messenger RNA Structure Related to Changes in the Translation of Different Messenger RNAs.- 3.5. Role of Messenger RNA Competition in Changing Relative Rates of Messenger RNA Utilization.- 3.6. Role of Messenger RNA Localization in Selective Translation 104 4. Conclusions.- References.- 6 Molecular Mechanisms of Translational Control during the Early Development of Xenopus laevis.- 1. Introduction.- 2. Oogenesis and Embryogenesis in Xenopus laevis.- 2.1. RNA and Protein Synthesis during Oogenesis.- 2.2. Messenger RNA Recruitment during Oocyte Maturation.- 2
... weniger
Bibliographische Angaben
- 2012, Softcover reprint of the original 1st ed. 1987, 510 Seiten, Maße: 15,2 x 22,9 cm, Kartoniert (TB), Englisch
- Herausgegeben: J. Ilan
- Verlag: Springer, Berlin
- ISBN-10: 146845367X
- ISBN-13: 9781468453676
Sprache:
Englisch
Kommentar zu "Translational Regulation of Gene Expression"
Schreiben Sie einen Kommentar zu "Translational Regulation of Gene Expression".
Kommentar verfassen