Yeast Systems Biology
Methods and Protocols
(Sprache: Englisch)
Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and...
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Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and principles governing the behavior of complex biological systems. Yeast Systems Biology: Methods and Protocols presents an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote, perspective on the latest experimental and computational techniques for systems biology studies, most of which were first designed for and validated in yeast, and selected examples of yeast systems biology studies and their applications in biotechnology and medicine. These experiments under controlled conditions can uncover the complexity and interplay of biological networks with their dynamics, basic principles of internal organization, and balanced orchestrated functions between organelles in direct interaction with the environment as well as the characterization of short and long-term effects of perturbations and dysregulation of networks that may illuminate the origin of complex human diseases. Written for the highly successful Methods in Molecular Biology(TM) series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results.
Practical and cutting-edge, Yeast Systems Biology: Methods and Protocols serves researchers interested in comprehensive systems biology strategies in well-defined model systems with specific objectives as well as a better knowledge of the latest post-genomic strategies at all 'omic levels and computational approaches towards analysis, integration, and modeling of biological systems, from single-celled organisms to higher eukaryotes.
Practical and cutting-edge, Yeast Systems Biology: Methods and Protocols serves researchers interested in comprehensive systems biology strategies in well-defined model systems with specific objectives as well as a better knowledge of the latest post-genomic strategies at all 'omic levels and computational approaches towards analysis, integration, and modeling of biological systems, from single-celled organisms to higher eukaryotes.
Klappentext zu „Yeast Systems Biology “
Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and principles governing the behavior of complex biological systems. Yeast Systems Biology: Methods and Protocols presents an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote, perspective on the latest experimental and computational techniques for systems biology studies, most of which were first designed for and validated in yeast, and selected examples of yeast systems biology studies and their applications in biotechnology and medicine. These experiments under controlled conditions can uncover the complexity and interplay of biological networks with their dynamics, basic principles of internal organization, and balanced orchestrated functions between organelles in direct interaction with the environment as well as the characterization of short and long-term effects of perturbations and dysregulation of networks that may illuminate the origin of complex human diseases. Written for the highly successful Methods in Molecular Biology(TM) series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results.
Practical and cutting-edge, Yeast Systems Biology: Methods and Protocols serves researchers interested in comprehensive systems biology strategies in well-defined model systems with specific objectives as well as a better knowledge of the latest post-genomic strategies at all 'omic levels and computational approaches towards analysis, integration, and modeling of biological systems, from single-celled organisms to higher eukaryotes.
Inhaltsverzeichnis zu „Yeast Systems Biology “
Part I: Yeast Systems Biology 1. Yeast Systems Biology: The Challenge of Eukaryotic Complexity; Juan I. Castrillo and Stephen G. Oliver
Part II: Experimental Systems Biology: High-Throughput Genome-Wide and Molecular Studies
2. Saccharomyces cerevisiae: Gene Annotation and Genome Variability, State-of-the-Art Through Comparative Genomics; Ed Louis
3. Genome-Wide Measurement of Histone H3 Replacement Dynamics in Yeast; Oliver J. Rando
4. Genome-Wide Approaches to Studying Yeast Chromatin Modifications; Dustin E. Schones, Kairong Cui, and Suresh Cuddapah
5. Absolute and Relative Quantification of mRNA Expression (Transcript Analysis); Andrew Hayes, Bharat M. Rash, and Leo A.H. Zeef
6. Enrichment of Unstable Non-Coding RNAs and Their Genome-Wide Identification; Helen Neil and Alain Jacquier
7. Genome-Wide Transcriptome Analysis in Yeast Using High-Density Tiling Arrays; Lior David, Sandra Clauder-Münster, and Lars M. Steinmetz
8. RNA Sequencing; Karl Waern, Ugrappa Nagalakshmi, and Michael Snyder
9. Polyadenylation State Microarray (PASTA) Analysis; Traude H Beilharz? and Thomas Preiss
10. Enabling Technologies for Yeast Proteome Analysis; Johanna Rees and Kathryn Lilley
11. Protein Turnover Methods in Single-Celled Organisms: Dynamic SILAC; Amy J. Claydon and Robert J. Beynon
12. Protein-Protein Interactions and Networks: Forward and Reverse Edgetics; Benoit Charloteaux, Quan Zhong, Matija Dreze, Michael E. Cusick, David E. Hill, and Marc Vidal
13. Use of Proteome Arrays to Globally Identify Substrates for E3 Ubiquitin Ligases; Avinash Persaud and Daniela Rotin
14. Fit for Purpose Quenching and Extraction Protocols for Metabolic Profiling of Yeast Using Chromatography-Mass Spectrometry Platforms; Catherine L. Winder and Warwick B. Dunn
15. The Automated Cell: Compound and Environment Screening System (ACCESS) for Chemogenomic Screening; Michael Proctor, Malene L. Urbanus, Eula L. Fung,
... mehr
Daniel F. Jaramillo, Ronald W. Davis, Corey Nislow, and Guri Giaever
16. Competition Experiments Coupled with High-Throughput Analyses for Functional Genomics Studies in Yeast; Daniela Delneri
17. Fluorescence Fluctuation Spectroscopy and Imaging Methods for Examination of Dynamic Protein Interactions in Yeast; Brian D. Slaughter, Jay R. Unruh, and Rong Li
18. Nutritional Control of Cell Growth Via TOR Signaling in Budding Yeast; Yuehua Wei and X.F. Steven Zheng
Part III: Computational Systems Biology: Computational Studies and Analyses
19. Computational Yeast Systems Biology: A Case Study for the MAP Kinase Cascade; Edda Klipp
20. Standards, Tools, and Databases for the Analysis of Yeast 'Omics Data; Axel Kowald and Christoph Wierling
21. A Computational Method to Search for DNA Structural Motifs in Functional Genomic Elements; Stephen C.J. Parker, Aaron Harlap, and Thomas D. Tullius
22. High Throughput Analyses and Curation of Protein Interactions in Yeast; Shoshana J. Wodak, Jim Vlasblom, and Shuye Pu
23. Noise in Biological Systems: Pros, Cons, and Mechanisms of Control; Yitzhak Pilpel
24. Genome-Scale Integrative Data Analysis and Modeling of Dynamic Processes in Yeast; Jean-Marc Schwartz and Claire Gaugain
25. Genome-Scale Metabolic Models of Saccharomyces cerevisiae; Intawat Nookaew, Roberto Olivares-Hernández, Sakarindr Bhumiratana, and Jens Nielsen
26. Representation, Simulation, and Hypothesis Generation in Graph and Logical Models of Biological Networks; Ken Whelan, Oliver Ray, and Ross King
27. Use of Genome-Scale Metabolic Models in Evolutionary Systems Biology; Balázs Papp, Balázs Szappanos, and Richard A. Notebaart
Part IV: Yeast Systems Biology in Practice: Saccharomyces cerevisiae as a Tool for Mammalian Studies
28. Saccharomyces cerevisiae Contributions Towards Understanding Mammalian Gene Function and Therapy; Nianshu Zhang and Elizabeth Bilsland
16. Competition Experiments Coupled with High-Throughput Analyses for Functional Genomics Studies in Yeast; Daniela Delneri
17. Fluorescence Fluctuation Spectroscopy and Imaging Methods for Examination of Dynamic Protein Interactions in Yeast; Brian D. Slaughter, Jay R. Unruh, and Rong Li
18. Nutritional Control of Cell Growth Via TOR Signaling in Budding Yeast; Yuehua Wei and X.F. Steven Zheng
Part III: Computational Systems Biology: Computational Studies and Analyses
19. Computational Yeast Systems Biology: A Case Study for the MAP Kinase Cascade; Edda Klipp
20. Standards, Tools, and Databases for the Analysis of Yeast 'Omics Data; Axel Kowald and Christoph Wierling
21. A Computational Method to Search for DNA Structural Motifs in Functional Genomic Elements; Stephen C.J. Parker, Aaron Harlap, and Thomas D. Tullius
22. High Throughput Analyses and Curation of Protein Interactions in Yeast; Shoshana J. Wodak, Jim Vlasblom, and Shuye Pu
23. Noise in Biological Systems: Pros, Cons, and Mechanisms of Control; Yitzhak Pilpel
24. Genome-Scale Integrative Data Analysis and Modeling of Dynamic Processes in Yeast; Jean-Marc Schwartz and Claire Gaugain
25. Genome-Scale Metabolic Models of Saccharomyces cerevisiae; Intawat Nookaew, Roberto Olivares-Hernández, Sakarindr Bhumiratana, and Jens Nielsen
26. Representation, Simulation, and Hypothesis Generation in Graph and Logical Models of Biological Networks; Ken Whelan, Oliver Ray, and Ross King
27. Use of Genome-Scale Metabolic Models in Evolutionary Systems Biology; Balázs Papp, Balázs Szappanos, and Richard A. Notebaart
Part IV: Yeast Systems Biology in Practice: Saccharomyces cerevisiae as a Tool for Mammalian Studies
28. Saccharomyces cerevisiae Contributions Towards Understanding Mammalian Gene Function and Therapy; Nianshu Zhang and Elizabeth Bilsland
... weniger
Bibliographische Angaben
- 2011, 535 Seiten, mit farbigen Abbildungen, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Ed. ny Juan I. Castrillo and Stephen G. Oliver
- Herausgegeben: Stephen G. Oliver, Juan I. Castrillo
- Verlag: Humana Press
- ISBN-10: 1617791725
- ISBN-13: 9781617791727
- Erscheinungsdatum: 23.08.2011
Sprache:
Englisch
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