ADME-Enabling Technologies in Drug Design and Development (PDF)
(Sprache: Englisch)
A comprehensive guide to cutting-edge tools in ADME research
The last decade has seen tremendous progress in the development
of analytical techniques such as mass spectrometry and molecular
biology tools, resulting in important advances in drug...
The last decade has seen tremendous progress in the development
of analytical techniques such as mass spectrometry and molecular
biology tools, resulting in important advances in drug...
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A comprehensive guide to cutting-edge tools in ADME research
The last decade has seen tremendous progress in the development
of analytical techniques such as mass spectrometry and molecular
biology tools, resulting in important advances in drug discovery,
particularly in the area of absorption, distribution, metabolism,
and excretion (ADME).
ADME-Enabling Technologies in Drug Design and Development
focuses on the current state of the art in the field, presenting a
comprehensive review of the latest tools for generating ADME data
in drug discovery. It examines the broadest possible range of
available technologies, giving readers the information they need to
choose the right tool for a given application, a key requisite for
obtaining favorable results in a timely fashion for regulatory
filings. With over thirty contributed chapters by an international
team of experts, the book provides:
* A thorough examination of current tools, covering both
electronic/mechanical technologies and biologically based ones
* Coverage of applications for each technology, including key
parameters, optimal conditions for intended results, protocols, and
case studies
* Detailed discussion of emerging tools and techniques, from stem
cells and genetically modified animal models to imaging
technologies
* Numerous figures and diagrams throughout the text
Scientists and researchers in drug metabolism, pharmacology,
medicinal chemistry, pharmaceutics, toxicology, and bioanalytical
science will find ADME-Enabling Technologies in Drug Design and
Development an invaluable guide to the entire drug development
process, from discovery to regulatory issues.
The last decade has seen tremendous progress in the development
of analytical techniques such as mass spectrometry and molecular
biology tools, resulting in important advances in drug discovery,
particularly in the area of absorption, distribution, metabolism,
and excretion (ADME).
ADME-Enabling Technologies in Drug Design and Development
focuses on the current state of the art in the field, presenting a
comprehensive review of the latest tools for generating ADME data
in drug discovery. It examines the broadest possible range of
available technologies, giving readers the information they need to
choose the right tool for a given application, a key requisite for
obtaining favorable results in a timely fashion for regulatory
filings. With over thirty contributed chapters by an international
team of experts, the book provides:
* A thorough examination of current tools, covering both
electronic/mechanical technologies and biologically based ones
* Coverage of applications for each technology, including key
parameters, optimal conditions for intended results, protocols, and
case studies
* Detailed discussion of emerging tools and techniques, from stem
cells and genetically modified animal models to imaging
technologies
* Numerous figures and diagrams throughout the text
Scientists and researchers in drug metabolism, pharmacology,
medicinal chemistry, pharmaceutics, toxicology, and bioanalytical
science will find ADME-Enabling Technologies in Drug Design and
Development an invaluable guide to the entire drug development
process, from discovery to regulatory issues.
Autoren-Porträt
Donglu Zhang, PhD, is a Principal Scientist in Pharmaceutical Candidate Optimization at Bristol-Myers Squibb in Princeton, New Jersey. He has published seventy peer-reviewed articles, codiscovered the Mass Defect Filtering technique, and coedited two books.Sekhar Surapaneni, PhD, is Director, DMPK, at Celgene Corporation in New Jersey. He has published extensively in peer-reviewed journals and is a member of ISSX and ACS.
Bibliographische Angaben
- 2012, 1. Auflage, 622 Seiten, Englisch
- Herausgegeben: Donglu Zhang, Sekhar Surapaneni
- Verlag: John Wiley & Sons
- ISBN-10: 1118180747
- ISBN-13: 9781118180747
- Erscheinungsdatum: 13.04.2012
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