Cardiovascular Safety in Drug Development and Therapeutic Use (PDF)
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With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant.
Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny problem, and begun to dissect the diverse mechanisms by which cardiac harm can occur with a variety of non-cardiac drugs. This is no easy task, given the complexity of the diseases we treat, and the wide spectrum of new therapies we seek to apply. However, it is an issue with which all health care providers must become familiar in order to prescribe appropriate therapy while safeguarding patients against avoidable and life-threatening cardiac adverse effects.
This compendium represents the state-of-the-art in the evolving field of cardiac safety and is vital reading for those interested in developing new chemical entities, as well as those who prescribe them and monitor patients for their hazard. As such, I recommend this book as essential reading for students, scientists, and health care providers at all levels of training.
Peter R. Kowey, MD, FACC, FAHA, FHRS
Lankenau Institute for Medical Research & Thomas Jefferson University
Dr Turner is currently Chief Scientific Advisor, Cardiac Safety Services, and Senior Scientific Director, Clinical Communications, Quintiles. He is also member of Quintiles' Cardiovascular and Diabetes Centers of Excellence. He is the author and co-author of over 120 publications in peer-reviewed journals, and the author, co-author,and editor of 15 books. Additionally, he holds the positions of Adjunct Professor of Pharmacy Practice, Campbell University College of Pharmacy & Health Sciences, and President and Chief Scientific Officer, Turner Medical Communications.
Dilip R. Karnad, MD, FACP, FRCP (Glasg), is an internist and an expert in cardiac safety with extensive clinical, research and teaching experience. He is currently Head of the Research Team, Cardiac Safety Services, Quintiles. He has a particular interest in statistical approaches to cardiac safety assessments, and has published over 20 papers in this field. He is a Fellow of the American College of Physicians and a Fellow of the Royal College of Physicians (of Glasgow), and also a practicing internist and critical care physician affiliated to Jupiter Hospital, Thane.
Snehal Kothari, MD, DM, FACC, FESC is a cardiologist and an expert in cardiac safety with extensive clinical, research and teaching experience. He is currently Chief Medical & Scientific Officer of the Core ECG Laboratory, Cardiac Safety Services, and Global Head
- Autoren: J. Rick Turner , Dilip R. Karnad , Snehal Kothari
- 2016, 1st ed. 2017, 342 Seiten, Englisch
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319403478
- ISBN-13: 9783319403472
- Erscheinungsdatum: 28.07.2016
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- Größe: 3.83 MB
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“Dr Turner and his colleagues have done the drug development community a service by providing a compendium of cardiovascular safety. They have done a masterful job of placing cardiovascular safety firmly within the context of overall drug development. As such, Cardiovascular Safety in Drug Development and Therapeutic Use is a book that should be on the shelf of every drug developer.” (Jonathan H. Seltzer, Therapeutic Innovation Regulatory Science, Vol. 51 (2), March, 2017)
“This book brings together a wealth of information … state-of-the-art knowledge on the mechanisms involved in drug-induced adverse cardiovascular effects and the investigational strategies available to characterise drugs for these effects. … The authors deserve our congratulations for their immense efforts and well-presented contribution to the scientific community. … It caters for all professionals interested in cardiovascular safety of drugs, including academic, regulatory and pharmaceutical scientists. I have no hesitation in recommending this book as a valuable reference source.” (Dr. Rashmi Shah, Journal for Clinical Studies, Vol. 9 (1), 2017)
“The aim is to provide researchers and clinicians fundamental knowledge in the field of biopharmaceutical cardiovascular safety in a comprehensive manner. This book is written for readers at all levels of involvement with drug development and therapeutic use, from pharmaceutical researchers to pharmacists and physicians. … Impressive features of the book include the extensive references and further reading lists at the end of each chapter … .” (John C. Gulotta, Doody's Book Reviews, November, 2016)
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