Computational Approaches for Identifying Drugs Against Alzheimer's Disease (PDF)
(Sprache: Englisch)
Alzheimer's disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the...
sofort als Download lieferbar
Printausgabe 39.99 €
eBook (pdf) -25%
29.99 €
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
Produktdetails
Produktinformationen zu „Computational Approaches for Identifying Drugs Against Alzheimer's Disease (PDF)“
Alzheimer's disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer's disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library. The concept of QSAR has typically been used for drug discovery and development and has gained wide applicability for correlating molecular information with not only biological activities but also with other physicochemical properties, which has therefore been termed quantitative structure-property relationship (QSPR). In this study, 3D QSAR and pharmacophore mapping studies were carried out using Accelrys Discovery Studio 2.1. The best nine drugs were selected from the 16 ligands and pharmacophore features were generated.
Bibliographische Angaben
- Autoren: Radha Mahendran , Suganya Jeyabaskar , Astral Gabriella Francis
- 2017, 1. Auflage, 68 Seiten, Englisch
- Verlag: Diplomica Verlag
- ISBN-10: 3960676387
- ISBN-13: 9783960676386
- Erscheinungsdatum: 23.03.2017
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: PDF
- Größe: 7.76 MB
- Ohne Kopierschutz
Sprache:
Englisch
Kommentar zu "Computational Approaches for Identifying Drugs Against Alzheimer's Disease"
Schreiben Sie einen Kommentar zu "Computational Approaches for Identifying Drugs Against Alzheimer's Disease".
Kommentar verfassen