Digital Twins / Advances in Biochemical Engineering/Biotechnology Bd.176 (PDF)
Both processes have undergone significant changes over the past few...
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Both processes have undergone significant changes over the past few decades, moving from data-driven approaches into the 21st-century digitalization of the bioprocess industry. Moreover, the high demand for biotechnological products calls for efficient methods during research and development, as well as during tech transfer and routine manufacturing.
In this regard, one promising tool is the use of digital twins, which offer a virtual representation of the bioprocess. They reflect the mechanistics of the biological system and the interactions between process parameters, key performance indicators and product quality attributes in the form of a mathematical process model. Furthermore, digital twins allow us to use computer-aided methods to gain an improved process understanding, to test and plan novel bioprocesses, and to efficiently monitor them.
This book explains the mathematical structure of digital twins, their development and the model's respective parts, as well as concepts for the knowledge-driven generation and structural variability of digital twins.
Covering fundamentals as well as applications, the two volumes offer the ideal introduction to the topic for researchers in academy and industry alike.
Christoph Herwig is a Full Professor of Biochemical Engineering at the Vienna University of Technology (Austria), with a background in Bioprocess Engineering from the RWTH Aachen (Germany) and Ph.D. in Bioprocess Identification at the EPFL (Switzerland). Prior to his Ph.D. graduation, he has also worked in industry in the design and commissioning of large chemical facilities. His main research focuses on the development of data science methods for integrated and efficient bioprocess development along PAT and QbD principles for biopharmaceuticals. In 2013 he founded the company Exputec addressing data science solutions for the biopharma life cycle, which was fused in Körber AG in 2020.
Ralf Pörtner studied Chemical Engineering at the University of Dortmund (Germany), and received his Ph.D. at the Department of Mechanical Process Engineering of the same university. After a post-doctoral study at the University of Tsukuba (Japan), he took on the role of Senior Engineer and Head of the working group "Cell Culture and Tissue Engineering" at the Technical University of Hamburg (Germany). Since 2010 he is Honorary Professor at TH Mittelhessen University of Applied Sciences, Giessen (Germany). He is currently one of the coordinators of the research focus "Regeneration, Implants and Medical Technology" of the Technical University of Hamburg (Germany), and member of the directorate of the Research Center Medical Technology (FMTHH). His main research activities include the development of bioreactors, in particular for cell cultures and microbial reactions, as well as model-based control concepts, and tissue engineering.
Johannes Möller studied Bioprocess Engineering at the Hamburg University of Technology (TUHH), Germany, where he did his Ph.D. and worked as a scientist at the Institute of Bioprocess and Biosystems Engineering (Head: Prof. An-Ping Zeng). His research focuses on accelerated and knowledge-driven
- 2021, 1st ed. 2021, 262 Seiten, Englisch
- Herausgegeben: Christoph Herwig, Ralf Pörtner, Johannes Möller
- Verlag: Springer International Publishing
- ISBN-10: 3030716600
- ISBN-13: 9783030716608
- Erscheinungsdatum: 25.04.2021
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- Größe: 10 MB
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