Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis / Progress in Inflammation Research Bd.89 (PDF)

Graham A. W. Rook, BA MB BChir MD, is emeritus Professor of Medical Microbiology at UCL (University College London). He was educated at the University of Cambridge and at St. Thomas' Hospital London. He became professor of medical microbiology at UCL in 1994. The theme of his research was initially the immunopathology of tuberculosis, but in recent years GR's focus has been the application of a Darwinian perspective to the effects on health of diminishing exposure to microorganisms from the natural environment, and of the changing composition of our commensal microbiota. GR coined the expression "Old Friends Hypothesis" to highlight a Darwinian re-interpretation of the hygiene hypothesis in 2003. Recently, in collaboration with neuroscientists and psychiatrists, this thinking has been applied to psychiatric disorders that are accompanied by persistently raised biomarkers of inflammation and to the reduced stress resilience of people living in high-income countries. Thus GR's approach is interdisciplinary, with emphasis on integrative physiology.

Christopher A. Lowry, Ph.D. is an Associate Professor in the Department of Integrative Physiology, Center for Neuroscience, and Center for Microbial Exploration at the University of Colorado Boulder, with a secondary appointment in the Department of Physical Medicine and Rehabilitation (PM&R) and Center for Neuroscience, University of Colorado Anschutz Medical Campus, a Principal Investigator in the Department of Veterans Affairs Eastern Colorado Health Care System, VA Rocky Mountain Mental Illness Research, Education, & Clinical Center (MIRECC), director of the Behavioral Neuroendocrinology Laboratory at CU Boulder, Co-Director of the Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), Senior Fellow and member of the Board of Directors of inVIVO Planetary Health, of the Worldwide Universities Network (WUN), and a member of the Board of Directors of Trails Please Foundation. Dr. Lowry's