Frontiers in Cancer Research (PDF)
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This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans.
Mel Greaves trained in Zoology and Immunology at University College in London and at the Karolinska Institute in Stockholm before focusing his research on cancer and leukaemia while at the Imperial Cancer Research Fund in London. Earlier in his career, he introduced novel, antibody/flow cytometry-based methods for biological classification of leukaemias that led to insights into the cellular origins of disease and more specific allocation of treatment. Greaves is responsible for establishing the first Leukaemia Research Fund Centre at The Institute of Cancer Research, London. His teams' work on the molecular genetics of childhood leukaemia uncovered the pre-natal origin of this disease and shed light on its possible infectious causes. His current research is focussed on stem cells, genetic architecture and clonal evolution in leukaemia and on the evolutionary biology
- 2016, 1st ed. 2016, 258 Seiten, Englisch
- Herausgegeben: Carlo C. Maley, Mel Greaves
- Verlag: Springer-Verlag GmbH
- ISBN-10: 1493964607
- ISBN-13: 9781493964604
- Erscheinungsdatum: 21.11.2016
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- Größe: 5.15 MB
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