Invertebrate Immunity / Advances in Experimental Medicine and Biology Bd.708 (PDF)

Keneth Söderhäll studied at Uppsala University and obtained his MSc degree in 1972 and PhD in 1978. He was promoted to associate professor (Docent) in 1980. After receiveing his PhD he worked in many different laboratories as a post-doc or as a guest scientist at the University of Montpellier/St.Christol, the Medical Cell Biology department at Tromsö University, the Millport Marine Biological Station in Scotland, University College of Wales in Swansea, the Marine Biological Laboratory at Woods Hole and John Hopkins University. In 1986 he held a Royal Society Fellowship at Swansea. In collaboration with Valerie J. Smith, he developed a new method to isolate and separate blood cells from invertebrates,which was based on using an anticoagulant with a low pH and EDTA , a method now used to isolate most invertebrate blood cells. When he returned to Uppsala he took a position as a researcher at the Swedish Science Research Council in 1987, obtaining a chair and appointment to professor and head of department at Uppsala University in 1989. He continued with research mainly on the proPO-system in arthropods. His group was first to clone proPO from an invertebrate and he has worked with this so-called melanization reaction for several years. His research team has also deciphered the clotting reaction in crustaceans and shown that it consists of a clotting protein present in plasma and a clotting enzyme, a transglutaminase present in the blood cells. This clotting system is distinct from that of a horseshoe crabs' in which a proteinase cascade demonstrates the great diversity in immune processes in invertebrates. He has published 230 original papers and 65 reviews in journals and books, and he has edited 4 books. He is presently on the editorial board on Fish and Shellfish Immunology, and is the editor of Journal of Experimental Biology. Dr. Söderhäll previously served on Journal Experimental Zoology, Animal Biology, Journal of Invertebrate Pathology and Developmental and