Molecular Targeted Radiosensitizers / Cancer Drug Discovery and Development (PDF)
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Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers.
Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
Iris Eke is currently a researcher at Stanford University. She earned her M.D. at the Technical University Munich, Germany. During her Ph.D. in Experimental Radiation Oncology at the Technical University Dresden, Germany, she focused on the innovative concept to target cell-extracellular matrix interactions to overcome radio- and chemoresistance and elucidated several new mechanistic insights. At the National Cancer Institute, National Institute of Health, Dr. Eke studied the mechanisms of tumor adaptation after multifractionated radiotherapy with the goal to identify novel potential drug therapy targets involving radiation-induced target activation and DNA repair.
- 2020, 1st ed. 2020, 364 Seiten, Englisch
- Herausgegeben: Henning Willers, Iris Eke
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3030497011
- ISBN-13: 9783030497019
- Erscheinungsdatum: 10.08.2020
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- Größe: 8.07 MB
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