Nanostructures for Antimicrobial and Antibiofilm Applications / Nanotechnology in the Life Sciences (PDF)
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In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications.
The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner.
The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit atarget of dreadful healthcare conditions such as cancer, immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties.
Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.
Busi Siddhardha, Ph.D. is a full-time Assistant Professor at the Department of Microbiology, Pondicherry University (a central university) Puducherry, India from 2011. Prior to joining the Pondicherry University, he was teaching at the Gurukul Kangri University, Haridwar. In brief, he has got more than 12 years of research and 7 years of teaching experience at the university level. Currently, there are five Ph.D. students under his guidance. He
Madhu Dyavaiah, Ph.D., is an Assistant Professor, in the Department of Biochemistry and Molecular Biology; Pondicherry University, Pondicherry. He has served as a Research Scientist in the Gen'NY'sis Center for Excellence in Cancer Genomic, University at Albany, USA (2006-2012), Postdoctoral fellow at Wadsworth Center, New York Dept. of Health, USA (2003-2006) and IISc. Bangalore, India (2002-2003). His research interest includes, Molecular Pathogenesis, DNA damage response, tRNA modification and translation regulation and aging biology. He has research experience in working with microbial pathogens includes, Cryptococcus, Candida and Fusarium spaces. Currently, he is working with different model systems such as S. cerevisiae and mice model to study the effect of natural compounds on age-related diseases including neurodegenerative diseases and cancer. He has been conferred with various prestigious awards in USA and India. He has served as referee for a number of International journals, including Food Sciences and Toxicology Research. He has more than 15 years of research and 8 years of teaching experience in Genomics, Proteomics, Molecular Biology, Clinical Biochemistry Biology and Drug Discovery. He has also published more than 20 research articles and a review in the peer-reviewed international journal, and authored three book chapters, which includes a chapter, "Yeasts: Candida and Cryptococcus" in the book entitled "Bacterial and Mycotic Infections in Immunocompromised Hosts: Clinical and Microbiological Aspects" He is a member of many scientific societies and organizations.
- 2020, 1st ed. 2020, 458 Seiten, Englisch
- Herausgegeben: Ram Prasad, Busi Siddhardha, Madhu Dyavaiah
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3030403378
- ISBN-13: 9783030403379
- Erscheinungsdatum: 12.05.2020
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